Cargando…

Thiolated 2-Methyl-β-Cyclodextrin as a Mucoadhesive Excipient for Poorly Soluble Drugs: Synthesis and Characterization

Thiolated cyclodextrins are structurally simple mucoadhesive macromolecules, which are able to host drugs and increase their apparent water solubility, as well as interact with the mucus layer prolonging drug residence time on the site of absorption. The aim of this study was to synthesize through g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grassiri, Brunella, Cesari, Andrea, Balzano, Federica, Migone, Chiara, Kali, Gergely, Bernkop-Schnürch, Andreas, Uccello-Barretta, Gloria, Zambito, Ylenia, Piras, Anna Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9370929/ https://www.ncbi.nlm.nih.gov/pubmed/35956685 http://dx.doi.org/10.3390/polym14153170

Ejemplares similares

Thiolated Hydroxypropyl-β-cyclodextrin: A Potential Multifunctional Excipient for Ocular Drug Delivery
por: Grassiri, Brunella, et al.
Publicado: (2022)

Intraoral Drug Delivery: Highly Thiolated κ-Carrageenan as Mucoadhesive Excipient
por: Kali, Gergely, et al.
Publicado: (2023)

Improvement of Peptide Affinity and Stability by Complexing to Cyclodextrin-Grafted Ammonium Chitosan
por: Cesari, Andrea, et al.
Publicado: (2020)

Thiolated Cellulose: A Dual-Acting Mucoadhesive and Permeation-Enhancing Polymer
por: Kali, Gergely, et al.
Publicado: (2023)

Thiolated silicone oil: Synthesis, gelling and mucoadhesive properties
por: Partenhauser, Alexandra, et al.
Publicado: (2015)

Thiolated Hyaluronic Acid as Versatile Mucoadhesive Polymer: From the Chemistry Behind to Product Developments—What Are the Capabilities?
por: Griesser, Janine, et al.
Publicado: (2018)

Per-6-Thiolated Cyclodextrins: A Novel Type of Permeation Enhancing Excipients for BCS Class IV Drugs
por: Asim, Mulazim Hussain, et al.
Publicado: (2020)

Chemical coupling of thiolated chitosan to preformed liposomes improves mucoadhesive properties
por: Gradauer, Kerstin, et al.
Publicado: (2012)

Non-ionic thiolated cyclodextrins – the next generation
por: Moghadam, Ali, et al.
Publicado: (2018)

Hydrolysis and Enantiodiscrimination of (R)- and (S)-Oxazepam Hemisuccinate by Methylated β-Cyclodextrins: An NMR Investigation
por: Cesari, Andrea, et al.
Publicado: (2021)

Corrigendum to “Thiolated silicone oil: Synthesis, gelling and mucoadhesive properties” [Acta Biomater. 16 (2015) 169–177]
por: Partenhauser, Alexandra, et al.
Publicado: (2015)

In Vitro Investigation of Thiolated Chitosan Derivatives as Mucoadhesive Coating Materials for Solid Lipid Nanoparticles
por: Wibel, Richard, et al.
Publicado: (2021)

Jellyfish Polysaccharides for Wound Healing Applications
por: Migone, Chiara, et al.
Publicado: (2022)

Silylated-Acetylated Cyclodextrins as Chiral Sensors for the Enantiodiscrimination of Fluorinated Anesthetics
por: Recchimurzo, Alessandra, et al.
Publicado: (2023)

Synthesis and Characterization of Thiolated Gum Ghatti as a Novel Excipient: Development of Compression-Coated Mucoadhesive Tablets of Domperidone
por: Puri, Vivek, et al.
Publicado: (2021)

S-Protected Thiolated Chitosan versus Thiolated Chitosan as Cell Adhesive Biomaterials for Tissue Engineering
por: Le-Vinh, Bao, et al.
Publicado: (2023)

Chiral Discrimination Mechanisms by Silylated-Acetylated Cyclodextrins: Superficial Interactions vs. Inclusion
por: Balzano, Federica, et al.
Publicado: (2022)

Thiolated Chitosans: A Multi-talented Class of Polymers for Various Applications
por: Federer, Christoph, et al.
Publicado: (2020)

Betaine- and L-Carnitine-Based Ionic Liquids as Solubilising and Stabilising Agents for the Formulation of Antimicrobial Eye Drops Containing Diacerein
por: Grassiri, Brunella, et al.
Publicado: (2023)

Nanoparticles Based on Quaternary Ammonium Chitosan-methyl-β-cyclodextrin Conjugate for the Neuropeptide Dalargin Delivery to the Central Nervous System: An In Vitro Study
por: Migone, Chiara, et al.
Publicado: (2020)

S-protected thiolated chitosan: Synthesis and in vitro characterization
por: Dünnhaupt, Sarah, et al.
Publicado: (2012)

Mucoadhesive Cyclodextrin-Modified Thiolated Poly(aspartic acid) as a Potential Ophthalmic Drug Delivery System
por: Budai-Szűcs, Mária, et al.
Publicado: (2018)

Chiral mono- and dicarbamates derived from ethyl (S)-lactate: convenient chiral solvating agents for the direct and efficient enantiodiscrimination of amino acid derivatives by (1)H NMR spectroscopy
por: Balzano, Federica, et al.
Publicado: (2020)

Preactivated thiomers as mucoadhesive polymers for drug delivery
por: Iqbal, Javed, et al.
Publicado: (2012)

Methyl-β-cyclodextrin quaternary ammonium chitosan conjugate: nanoparticles vs macromolecular soluble complex
por: Piras, Anna Maria, et al.
Publicado: (2018)

Thiolated Nanoparticles for Biomedical Applications: Mimicking the Workhorses of Our Body
por: Hock, Nathalie, et al.
Publicado: (2021)

Biopharmaceutical Assessment of Mesh Aerosolised Plasminogen, a Step towards ARDS Treatment
por: Vizzoni, Lucia, et al.
Publicado: (2023)

Diaminated Starch: A Competitor of Chitosan with Highly Mucoadhesive Properties due to Increased Local Cationic Charge Density
por: Nouri, Akram, et al.
Publicado: (2020)

Connecting the solution chemistry of PbI(2) and MAI: a cyclodextrin-based supramolecular approach to the formation of hybrid halide perovskites
por: Masi, Sofia, et al.
Publicado: (2018)

Thiourea Derivative of 2-[(1R)-1-Aminoethyl]phenol: A Flexible Pocket-like Chiral Solvating Agent (CSA) for the Enantiodifferentiation of Amino Acid Derivatives by NMR Spectroscopy
por: Recchimurzo, Alessandra, et al.
Publicado: (2020)

A Dimeric Thiourea CSA for the Enantiodiscrimination of Amino Acid Derivatives by NMR Spectroscopy
por: Recchimurzo, Alessandra, et al.
Publicado: (2021)

Renewable Resources for Enantiodiscrimination: Chiral Solvating Agents for NMR Spectroscopy from Isomannide and Isosorbide
por: Balzano, Federica, et al.
Publicado: (2022)

Bis-Thiourea Chiral Sensor for the NMR Enantiodiscrimination of N-Acetyl and N-Trifluoroacetyl Amino Acid Derivatives
por: Recchimurzo, Alessandra, et al.
Publicado: (2022)

The Phenomenon of Self-Induced Diastereomeric Anisochrony and Its Implications in NMR Spectroscopy
por: Aiello, Federica, et al.
Publicado: (2023)

Synthesis of Thiolated Alginate and Evaluation of Mucoadhesiveness, Cytotoxicity and Release Retardant Properties
por: Jindal, A. B., et al.
Publicado: (2010)

Liposomes coated with thiolated chitosan enhance oral peptide delivery to rats()
por: Gradauer, K., et al.
Publicado: (2013)

Development and In Vitro Evaluation of Stearic Acid Phosphotyrosine Amide as New Excipient for Zeta Potential Changing Self-Emulsifying Drug Delivery Systems
por: Prüfert, Felix, et al.
Publicado: (2020)

Impact of Different Mucoadhesive Polymeric Nanoparticles Loaded in Thermosensitive Hydrogels on Transcorneal Administration of 5-Fluorouracil
por: Fabiano, Angela, et al.
Publicado: (2019)

Less Reactive Thiol Ligands: Key towards Highly Mucoadhesive Drug Delivery Systems
por: Shahzadi, Iram, et al.
Publicado: (2020)

Synthesis and characterization of thiolated hexanoyl glycol chitosan as a mucoadhesive thermogelling polymer
por: Cho, Ik Sung, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_muplare6qhksjfsfg4q82rje3q