Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface

Galanin is a neuropeptide expressed in the central and peripheral nervous systems, where it regulates various processes including neuroendocrine release, cognition, and nerve regeneration. Three G-protein coupled receptors (GPCRs) for galanin have been discovered, which is the focus of efforts to tr...

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Detalles Bibliográficos
Autores principales: Heo, Yunseok, Ishimoto, Naito, Jeon, Ye-Eun, Yun, Ji-Hye, Ohki, Mio, Anraku, Yuki, Sasaki, Mina, Kita, Shunsuke, Fukuhara, Hideo, Ikuta, Tatsuya, Kawakami, Kouki, Inoue, Asuka, Maenaka, Katsumi, Tame, Jeremy R. H., Lee, Weontae, Park, Sam-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371267/
https://www.ncbi.nlm.nih.gov/pubmed/35913979
http://dx.doi.org/10.1371/journal.pbio.3001714

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