Cargando…
Direct Conversion X-ray Detector with Micron-Scale Pixel Pitch for Edge-Illumination and Propagation-Based X-ray Phase-Contrast Imaging
In this work, we investigate the potential of employing a direct conversion integration mode X-ray detector with micron-scale pixels in two different X-ray phase-contrast imaging (XPCi) configurations, propagation-based (PB) and edge illumination (EI). Both PB-XPCi and EI-XPCi implementations are ev...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371434/ https://www.ncbi.nlm.nih.gov/pubmed/35957449 http://dx.doi.org/10.3390/s22155890 |
_version_ | 1784767141275238400 |
---|---|
author | Pil-Ali, Abdollah Adnani, Sahar Scott, Christopher C. Karim, Karim S. |
author_facet | Pil-Ali, Abdollah Adnani, Sahar Scott, Christopher C. Karim, Karim S. |
author_sort | Pil-Ali, Abdollah |
collection | PubMed |
description | In this work, we investigate the potential of employing a direct conversion integration mode X-ray detector with micron-scale pixels in two different X-ray phase-contrast imaging (XPCi) configurations, propagation-based (PB) and edge illumination (EI). Both PB-XPCi and EI-XPCi implementations are evaluated through a wave optics model—numerically simulated in MATLAB—and are compared based on their contrast, edge-enhancement, visibility, and dose efficiency characteristics. The EI-XPCi configuration, in general, demonstrates higher performance compared to PB-XPCi, considering a setup with the same X-ray source and detector. However, absorption masks quality (thickness of X-ray absorption material) and environmental vibration effect are two potential challenges for EI-XPCi employing a detector with micron-scale pixels. Simulation results confirm that the behavior of an EI-XPCi system employing a high-resolution detector is susceptible to its absorption masks thickness and misalignment. This work demonstrates the potential and feasibility of employing a high-resolution direct conversion detector for phase-contrast imaging applications where higher dose efficiency, higher contrast images, and a more compact imaging system are of interest. |
format | Online Article Text |
id | pubmed-9371434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93714342022-08-12 Direct Conversion X-ray Detector with Micron-Scale Pixel Pitch for Edge-Illumination and Propagation-Based X-ray Phase-Contrast Imaging Pil-Ali, Abdollah Adnani, Sahar Scott, Christopher C. Karim, Karim S. Sensors (Basel) Article In this work, we investigate the potential of employing a direct conversion integration mode X-ray detector with micron-scale pixels in two different X-ray phase-contrast imaging (XPCi) configurations, propagation-based (PB) and edge illumination (EI). Both PB-XPCi and EI-XPCi implementations are evaluated through a wave optics model—numerically simulated in MATLAB—and are compared based on their contrast, edge-enhancement, visibility, and dose efficiency characteristics. The EI-XPCi configuration, in general, demonstrates higher performance compared to PB-XPCi, considering a setup with the same X-ray source and detector. However, absorption masks quality (thickness of X-ray absorption material) and environmental vibration effect are two potential challenges for EI-XPCi employing a detector with micron-scale pixels. Simulation results confirm that the behavior of an EI-XPCi system employing a high-resolution detector is susceptible to its absorption masks thickness and misalignment. This work demonstrates the potential and feasibility of employing a high-resolution direct conversion detector for phase-contrast imaging applications where higher dose efficiency, higher contrast images, and a more compact imaging system are of interest. MDPI 2022-08-07 /pmc/articles/PMC9371434/ /pubmed/35957449 http://dx.doi.org/10.3390/s22155890 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pil-Ali, Abdollah Adnani, Sahar Scott, Christopher C. Karim, Karim S. Direct Conversion X-ray Detector with Micron-Scale Pixel Pitch for Edge-Illumination and Propagation-Based X-ray Phase-Contrast Imaging |
title | Direct Conversion X-ray Detector with Micron-Scale Pixel Pitch for Edge-Illumination and Propagation-Based X-ray Phase-Contrast Imaging |
title_full | Direct Conversion X-ray Detector with Micron-Scale Pixel Pitch for Edge-Illumination and Propagation-Based X-ray Phase-Contrast Imaging |
title_fullStr | Direct Conversion X-ray Detector with Micron-Scale Pixel Pitch for Edge-Illumination and Propagation-Based X-ray Phase-Contrast Imaging |
title_full_unstemmed | Direct Conversion X-ray Detector with Micron-Scale Pixel Pitch for Edge-Illumination and Propagation-Based X-ray Phase-Contrast Imaging |
title_short | Direct Conversion X-ray Detector with Micron-Scale Pixel Pitch for Edge-Illumination and Propagation-Based X-ray Phase-Contrast Imaging |
title_sort | direct conversion x-ray detector with micron-scale pixel pitch for edge-illumination and propagation-based x-ray phase-contrast imaging |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371434/ https://www.ncbi.nlm.nih.gov/pubmed/35957449 http://dx.doi.org/10.3390/s22155890 |
work_keys_str_mv | AT pilaliabdollah directconversionxraydetectorwithmicronscalepixelpitchforedgeilluminationandpropagationbasedxrayphasecontrastimaging AT adnanisahar directconversionxraydetectorwithmicronscalepixelpitchforedgeilluminationandpropagationbasedxrayphasecontrastimaging AT scottchristopherc directconversionxraydetectorwithmicronscalepixelpitchforedgeilluminationandpropagationbasedxrayphasecontrastimaging AT karimkarims directconversionxraydetectorwithmicronscalepixelpitchforedgeilluminationandpropagationbasedxrayphasecontrastimaging |