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Lentinan -triggered butyrate-producing bacteria drive the expulsion of the intestinal helminth Trichinella spiralis in mice

Trichinellosis caused by Trichinella spiralis is a serious zoonosis with a worldwide distribution. Lentinan (LNT) is known to modulate the intestinal environment with noted health benefits, yet the effect of LNT against intestinal helminth is unknown. In our study, we first observed that LNT could t...

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Autores principales: Jin, Xuemin, Liu, Yi, Vallee, Isabelle, Karadjian, Gregory, Liu, Mingyuan, Liu, Xiaolei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371446/
https://www.ncbi.nlm.nih.gov/pubmed/35967395
http://dx.doi.org/10.3389/fimmu.2022.926765
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author Jin, Xuemin
Liu, Yi
Vallee, Isabelle
Karadjian, Gregory
Liu, Mingyuan
Liu, Xiaolei
author_facet Jin, Xuemin
Liu, Yi
Vallee, Isabelle
Karadjian, Gregory
Liu, Mingyuan
Liu, Xiaolei
author_sort Jin, Xuemin
collection PubMed
description Trichinellosis caused by Trichinella spiralis is a serious zoonosis with a worldwide distribution. Lentinan (LNT) is known to modulate the intestinal environment with noted health benefits, yet the effect of LNT against intestinal helminth is unknown. In our study, we first observed that LNT could trigger worm expulsion by promoting mucus layer functions through alteration of gut microbiota. LNT restored the abundance of Bacteroidetes and Proteobacteria altered by T. spiralis infection to the control group level. Interestingly, LNT triggered the production of butyrate. Then, we determined the deworming capacity of probiotics (butyrate-producing bacteria) in mice. Collectively, these findings indicated that LNT could modulate intestinal dysbiosis by T. spiralis, drive the expulsion of intestinal helminth and provided an easily implementable strategy to improve the host defence against T. spiralis infection.
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spelling pubmed-93714462022-08-12 Lentinan -triggered butyrate-producing bacteria drive the expulsion of the intestinal helminth Trichinella spiralis in mice Jin, Xuemin Liu, Yi Vallee, Isabelle Karadjian, Gregory Liu, Mingyuan Liu, Xiaolei Front Immunol Immunology Trichinellosis caused by Trichinella spiralis is a serious zoonosis with a worldwide distribution. Lentinan (LNT) is known to modulate the intestinal environment with noted health benefits, yet the effect of LNT against intestinal helminth is unknown. In our study, we first observed that LNT could trigger worm expulsion by promoting mucus layer functions through alteration of gut microbiota. LNT restored the abundance of Bacteroidetes and Proteobacteria altered by T. spiralis infection to the control group level. Interestingly, LNT triggered the production of butyrate. Then, we determined the deworming capacity of probiotics (butyrate-producing bacteria) in mice. Collectively, these findings indicated that LNT could modulate intestinal dysbiosis by T. spiralis, drive the expulsion of intestinal helminth and provided an easily implementable strategy to improve the host defence against T. spiralis infection. Frontiers Media S.A. 2022-07-28 /pmc/articles/PMC9371446/ /pubmed/35967395 http://dx.doi.org/10.3389/fimmu.2022.926765 Text en Copyright © 2022 Jin, Liu, Vallee, Karadjian, Liu and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Jin, Xuemin
Liu, Yi
Vallee, Isabelle
Karadjian, Gregory
Liu, Mingyuan
Liu, Xiaolei
Lentinan -triggered butyrate-producing bacteria drive the expulsion of the intestinal helminth Trichinella spiralis in mice
title Lentinan -triggered butyrate-producing bacteria drive the expulsion of the intestinal helminth Trichinella spiralis in mice
title_full Lentinan -triggered butyrate-producing bacteria drive the expulsion of the intestinal helminth Trichinella spiralis in mice
title_fullStr Lentinan -triggered butyrate-producing bacteria drive the expulsion of the intestinal helminth Trichinella spiralis in mice
title_full_unstemmed Lentinan -triggered butyrate-producing bacteria drive the expulsion of the intestinal helminth Trichinella spiralis in mice
title_short Lentinan -triggered butyrate-producing bacteria drive the expulsion of the intestinal helminth Trichinella spiralis in mice
title_sort lentinan -triggered butyrate-producing bacteria drive the expulsion of the intestinal helminth trichinella spiralis in mice
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371446/
https://www.ncbi.nlm.nih.gov/pubmed/35967395
http://dx.doi.org/10.3389/fimmu.2022.926765
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