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Does protracted chemotherapy have an influence on the clinical outcomes in advanced epithelial ovarian cancer?
In epithelial ovarian cancer, first-line adjuvant chemotherapy is necessary, and patients sometimes require protraction; however, there are only a few recent studies to show its influence. In this study, we investigated whether the protraction of the total period of first-line chemotherapy has a neg...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371530/ https://www.ncbi.nlm.nih.gov/pubmed/35960085 http://dx.doi.org/10.1097/MD.0000000000029967 |
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author | Lee, Juhun Hong, Dae Gy |
author_facet | Lee, Juhun Hong, Dae Gy |
author_sort | Lee, Juhun |
collection | PubMed |
description | In epithelial ovarian cancer, first-line adjuvant chemotherapy is necessary, and patients sometimes require protraction; however, there are only a few recent studies to show its influence. In this study, we investigated whether the protraction of the total period of first-line chemotherapy has a negative influence on the survival outcomes. Of the 101 patients we recruited from February 2011 to February 2021, 70 (69.3%) and 31 (30.7%) were classified into the not protracted and protracted groups, respectively. They underwent surgery and adjuvant chemotherapy for epithelial ovarian cancer. Protraction was defined as the overall duration of the first-line chemotherapy being more than 20 days longer than intended. Number of patients who underwent additional treatments such as bevacizumab or poly(adenosine diphosphate ribose) polymerase inhibitors or pembrolizumab was compared between both groups. Kaplan–Meier survival analysis and Cox regression analysis were used for survival outcomes. There was no significant difference for additional treatments. The progression-free survival (PFS) in the total follow-up period in the protracted group was significantly shorter than that in the not protracted group (P = .037); however, the difference in the overall survival between the 2 groups was not significant (P = .223). For the PFS, the hazard ratio of protraction was 1.646 in the univariate analysis (95% confidence interval, 1.020–2.658; P = .041). Excessive protraction of chemotherapy over 20 days or more can result in significantly shorter PFS within 5 years. A better therapeutic strategy is required for patients requiring protracted first-line chemotherapy in advanced epithelial ovarian cancer. |
format | Online Article Text |
id | pubmed-9371530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-93715302022-08-16 Does protracted chemotherapy have an influence on the clinical outcomes in advanced epithelial ovarian cancer? Lee, Juhun Hong, Dae Gy Medicine (Baltimore) Research Article In epithelial ovarian cancer, first-line adjuvant chemotherapy is necessary, and patients sometimes require protraction; however, there are only a few recent studies to show its influence. In this study, we investigated whether the protraction of the total period of first-line chemotherapy has a negative influence on the survival outcomes. Of the 101 patients we recruited from February 2011 to February 2021, 70 (69.3%) and 31 (30.7%) were classified into the not protracted and protracted groups, respectively. They underwent surgery and adjuvant chemotherapy for epithelial ovarian cancer. Protraction was defined as the overall duration of the first-line chemotherapy being more than 20 days longer than intended. Number of patients who underwent additional treatments such as bevacizumab or poly(adenosine diphosphate ribose) polymerase inhibitors or pembrolizumab was compared between both groups. Kaplan–Meier survival analysis and Cox regression analysis were used for survival outcomes. There was no significant difference for additional treatments. The progression-free survival (PFS) in the total follow-up period in the protracted group was significantly shorter than that in the not protracted group (P = .037); however, the difference in the overall survival between the 2 groups was not significant (P = .223). For the PFS, the hazard ratio of protraction was 1.646 in the univariate analysis (95% confidence interval, 1.020–2.658; P = .041). Excessive protraction of chemotherapy over 20 days or more can result in significantly shorter PFS within 5 years. A better therapeutic strategy is required for patients requiring protracted first-line chemotherapy in advanced epithelial ovarian cancer. Lippincott Williams & Wilkins 2022-08-12 /pmc/articles/PMC9371530/ /pubmed/35960085 http://dx.doi.org/10.1097/MD.0000000000029967 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Lee, Juhun Hong, Dae Gy Does protracted chemotherapy have an influence on the clinical outcomes in advanced epithelial ovarian cancer? |
title | Does protracted chemotherapy have an influence on the clinical outcomes in advanced epithelial ovarian cancer? |
title_full | Does protracted chemotherapy have an influence on the clinical outcomes in advanced epithelial ovarian cancer? |
title_fullStr | Does protracted chemotherapy have an influence on the clinical outcomes in advanced epithelial ovarian cancer? |
title_full_unstemmed | Does protracted chemotherapy have an influence on the clinical outcomes in advanced epithelial ovarian cancer? |
title_short | Does protracted chemotherapy have an influence on the clinical outcomes in advanced epithelial ovarian cancer? |
title_sort | does protracted chemotherapy have an influence on the clinical outcomes in advanced epithelial ovarian cancer? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371530/ https://www.ncbi.nlm.nih.gov/pubmed/35960085 http://dx.doi.org/10.1097/MD.0000000000029967 |
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