Mechanistic details of CRISPR-associated transposon recruitment and integration revealed by cryo-EM

CRISPR-associated transposons (CASTs) are Tn7-like elements that are capable of RNA-guided DNA integration. Although structural data are known for nearly all core transposition components, the transposase component, TnsB, remains uncharacterized. Using cryo-electron microscopy (cryo-EM) structure de...

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Detalles Bibliográficos
Autores principales: Park, Jung-Un, Tsai, Amy Wei-Lun, Chen, Tiffany H., Peters, Joseph E., Kellogg, Elizabeth H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371665/
https://www.ncbi.nlm.nih.gov/pubmed/35914146
http://dx.doi.org/10.1073/pnas.2202590119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371665/
https://www.ncbi.nlm.nih.gov/pubmed/35914146
http://dx.doi.org/10.1073/pnas.2202590119

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