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Chemical interference with DSIF complex formation lowers synthesis of mutant huntingtin gene products and curtails mutant phenotypes

Earlier work has shown that siRNA-mediated reduction of the SUPT4H or SUPT5H proteins, which interact to form the DSIF complex and facilitate transcript elongation by RNA polymerase II (RNAPII), can decrease expression of mutant gene alleles containing nucleotide repeat expansions differentially. Us...

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Detalles Bibliográficos
Autores principales:	Deng, Ning, Wu, Yun-Yun, Feng, Yanan, Hsieh, Wen-Chieh, Song, Jen-Shin, Lin, Yu-Shiuan, Tseng, Ya-Hsien, Liao, Wan-Jhu, Chu, Yi-Fan, Liu, Yu-Cheng, Chang, En-Cheng, Liu, Chia-Rung, Sheu, Sheh-Yi, Su, Ming-Tsan, Kuo, Hung-Chih, Cohen, Stanley N., Cheng, Tzu-Hao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371670/ https://www.ncbi.nlm.nih.gov/pubmed/35914128 http://dx.doi.org/10.1073/pnas.2204779119

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