Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation

Histone acetylation is a key component in the consolidation of long-term fear memories. Histone acetylation is fueled by acetyl-coenzyme A (acetyl-CoA), and recently, nuclear-localized metabolic enzymes that produce this metabolite have emerged as direct and local regulators of chromatin. In particu...

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Detalles Bibliográficos
Autores principales: Alexander, Desi C., Corman, Tanya, Mendoza, Mariel, Glass, Andrew, Belity, Tal, Wu, Ranran, Campbell, Rianne R., Han, Joseph, Keiser, Ashley A., Winkler, Jeffrey, Wood, Marcelo A., Kim, Thomas, Garcia, Benjamin A., Cohen, Hagit, Mews, Philipp, Egervari, Gabor, Berger, Shelley L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371679/
https://www.ncbi.nlm.nih.gov/pubmed/35921439
http://dx.doi.org/10.1073/pnas.2114758119

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