SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation

Viruses evade the innate immune response by suppressing the production or activity of cytokines such as type I interferons (IFNs). Here we report the discovery of a mechanism by which the SARS-CoV-2 virus coopts an intrinsic cellular machinery to suppress the production of the key immunostimulatory...

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Detalles Bibliográficos
Autores principales: Xu, Zhang, Choi, Jung-Hyun, Dai, David L., Luo, Jun, Ladak, Reese Jalal, Li, Qian, Wang, Yimeng, Zhang, Christine, Wiebe, Shane, Liu, Alex C. H., Ran, Xiaozhuo, Yang, Jiaqi, Naeli, Parisa, Garzia, Aitor, Zhou, Lele, Mahmood, Niaz, Deng, Qiyun, Elaish, Mohamed, Lin, Rongtuan, Mahal, Lara K., Hobman, Tom C., Pelletier, Jerry, Alain, Tommy, Vidal, Silvia M., Duchaine, Thomas, Mazhab-Jafari, Mohammad T., Mao, Xiaojuan, Jafarnejad, Seyed Mehdi, Sonenberg, Nahum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371684/
https://www.ncbi.nlm.nih.gov/pubmed/35878012
http://dx.doi.org/10.1073/pnas.2204539119

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