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Molecular mechanism for strengthening E-cadherin adhesion using a monoclonal antibody

E-cadherin (Ecad) is an essential cell–cell adhesion protein with tumor suppression properties. The adhesive state of Ecad can be modified by the monoclonal antibody 19A11, which has potential applications in reducing cancer metastasis. Using X-ray crystallography, we determine the structure of 19A1...

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Detalles Bibliográficos
Autores principales:	Xie, Bin, Maker, Allison, Priest, Andrew V., Dranow, David M., Phan, Jenny N., Edwards, Thomas E., Staker, Bart L., Myler, Peter J., Gumbiner, Barry M., Sivasankar, Sanjeevi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371698/ https://www.ncbi.nlm.nih.gov/pubmed/35921442 http://dx.doi.org/10.1073/pnas.2204473119

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