Cell-penetrating peptides enhance peptide vaccine accumulation and persistence in lymph nodes to drive immunogenicity

Peptide-based cancer vaccines are widely investigated in the clinic but exhibit modest immunogenicity. One approach that has been explored to enhance peptide vaccine potency is covalent conjugation of antigens with cell-penetrating peptides (CPPs), linear cationic and amphiphilic peptide sequences d...

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Detalles Bibliográficos
Autores principales: Backlund, Coralie M., Holden, Rebecca L., Moynihan, Kelly D., Garafola, Daniel, Farquhar, Charlotte, Mehta, Naveen K., Maiorino, Laura, Pham, Sydney, Iorgulescu, J. Bryan, Reardon, David A., Wu, Catherine J., Pentelute, Bradley L., Irvine, Darrell J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371699/
https://www.ncbi.nlm.nih.gov/pubmed/35914154
http://dx.doi.org/10.1073/pnas.2204078119

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