Characterization of T cell receptors reactive to HCRT(NH2), pHA(273-287), and NP(17-31) in control and narcolepsy patients

Narcolepsy type 1 (NT1), a disorder caused by hypocretin/orexin (HCRT) cell loss, is associated with human leukocyte antigen (HLA)-DQ0602 (98%) and T cell receptor (TCR) polymorphisms. Increased CD4(+) T cell reactivity to HCRT, especially DQ0602-presented amidated C-terminal HCRT (HCRT(NH2)), has b...

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Detalles Bibliográficos
Autores principales: Luo, Guo, Zhang, Jing, Lin, Ling, Mignot, Emmanuel Jean-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371724/
https://www.ncbi.nlm.nih.gov/pubmed/35914171
http://dx.doi.org/10.1073/pnas.2205797119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371724/
https://www.ncbi.nlm.nih.gov/pubmed/35914171
http://dx.doi.org/10.1073/pnas.2205797119

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