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Characterization of T cell receptors reactive to HCRT(NH2), pHA(273-287), and NP(17-31) in control and narcolepsy patients
Narcolepsy type 1 (NT1), a disorder caused by hypocretin/orexin (HCRT) cell loss, is associated with human leukocyte antigen (HLA)-DQ0602 (98%) and T cell receptor (TCR) polymorphisms. Increased CD4(+) T cell reactivity to HCRT, especially DQ0602-presented amidated C-terminal HCRT (HCRT(NH2)), has b...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371724/ https://www.ncbi.nlm.nih.gov/pubmed/35914171 http://dx.doi.org/10.1073/pnas.2205797119 |