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Postmitotic accumulation of histone variant H3.3 in new cortical neurons establishes neuronal chromatin, transcriptome, and identity
Histone variants, which can be expressed outside of S-phase and deposited DNA synthesis-independently, provide long-term histone replacement in postmitotic cells, including neurons. Beyond replenishment, histone variants also play active roles in gene regulation by modulating chromatin states or ena...
Autores principales: | Funk, Owen H., Qalieh, Yaman, Doyle, Daniel Z., Lam, Mandy M., Kwan, Kenneth Y. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371731/ https://www.ncbi.nlm.nih.gov/pubmed/35930666 http://dx.doi.org/10.1073/pnas.2116956119 |
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