QTQTN motif upstream of the furin-cleavage site plays a key role in SARS-CoV-2 infection and pathogenesis

The furin cleavage site (FCS), an unusual feature in the SARS-CoV-2 spike protein, has been spotlighted as a factor key to facilitating infection and pathogenesis by increasing spike processing. Similarly, the QTQTN motif directly upstream of the FCS is also an unusual feature for group 2B coronavir...

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Detalles Bibliográficos
Autores principales: Vu, Michelle N., Lokugamage, Kumari G., Plante, Jessica A., Scharton, Dionna, Bailey, Aaron O., Sotcheff, Stephanea, Swetnam, Daniele M., Johnson, Bryan A., Schindewolf, Craig, Alvarado, R. Elias, Crocquet-Valdes, Patricia A., Debbink, Kari, Weaver, Scott C., Walker, David H., Russell, William K., Routh, Andrew L., Plante, Kenneth S., Menachery, Vineet D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371735/
https://www.ncbi.nlm.nih.gov/pubmed/35881779
http://dx.doi.org/10.1073/pnas.2205690119

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