Insights into innate immune activation via PS-ASO–protein–TLR9 interactions

Non-CpG PS-ASOs can activate the innate immune system, leading to undesired outcomes. This response can vary—in part—as a function of 2′modifications and sequence. Here we investigated the molecular steps involved in the varied effects of PS-ASOs on the innate immune system. We found that pro-inflam...

Descripción completa

Detalles Bibliográficos
Autores principales: Pollak, Adam J, Zhao, Luyi, Vickers, Timothy A, Huggins, Ian J, Liang, Xue-Hai, Crooke, Stanley T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371907/
https://www.ncbi.nlm.nih.gov/pubmed/35848907
http://dx.doi.org/10.1093/nar/gkac618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371907/
https://www.ncbi.nlm.nih.gov/pubmed/35848907
http://dx.doi.org/10.1093/nar/gkac618

Ejemplares similares