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Insights into innate immune activation via PS-ASO–protein–TLR9 interactions

Non-CpG PS-ASOs can activate the innate immune system, leading to undesired outcomes. This response can vary—in part—as a function of 2′modifications and sequence. Here we investigated the molecular steps involved in the varied effects of PS-ASOs on the innate immune system. We found that pro-inflam...

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Detalles Bibliográficos
Autores principales:	Pollak, Adam J, Zhao, Luyi, Vickers, Timothy A, Huggins, Ian J, Liang, Xue-Hai, Crooke, Stanley T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371907/ https://www.ncbi.nlm.nih.gov/pubmed/35848907 http://dx.doi.org/10.1093/nar/gkac618

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