Cap-independent translation and a precisely located RNA sequence enable SARS-CoV-2 to control host translation and escape anti-viral response

Translation of SARS-CoV-2-encoded mRNAs by the host ribosomes is essential for its propagation. Following infection, the early expressed viral protein NSP1 binds the ribosome, represses translation, and induces mRNA degradation, while the host elicits an anti-viral response. The mechanisms enabling...

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Detalles Bibliográficos
Autores principales: Slobodin, Boris, Sehrawat, Urmila, Lev, Anastasia, Hayat, Daniel, Zuckerman, Binyamin, Fraticelli, Davide, Ogran, Ariel, Ben-Shmuel, Amir, Bar-David, Elad, Levy, Haim, Ulitsky, Igor, Dikstein, Rivka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371909/
https://www.ncbi.nlm.nih.gov/pubmed/35849342
http://dx.doi.org/10.1093/nar/gkac615

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