Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ϵ variants at low dNTP levels

Amino acid substitutions in the exonuclease domain of DNA polymerase ϵ (Polϵ) cause ultramutated tumors. Studies in model organisms suggested pathogenic mechanisms distinct from a simple loss of exonuclease. These mechanisms remain unclear for most recurrent Polϵ mutations. Particularly, the highly...

Descripción completa

Detalles Bibliográficos
Autores principales: Barbari, Stephanie R, Beach, Annette K, Markgren, Joel G, Parkash, Vimal, Moore, Elizabeth A, Johansson, Erik, Shcherbakova, Polina V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371911/
https://www.ncbi.nlm.nih.gov/pubmed/35822874
http://dx.doi.org/10.1093/nar/gkac602

Ejemplares similares

Ejemplares similares