HDAC1 and PRC2 mediate combinatorial control in SPI1/PU.1-dependent gene repression in murine erythroleukaemia

Although originally described as transcriptional activator, SPI1/PU.1, a major player in haematopoiesis whose alterations are associated with haematological malignancies, has the ability to repress transcription. Here, we investigated the mechanisms underlying gene repression in the erythroid lineag...

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Detalles Bibliográficos
Autores principales: Gregoricchio, Sebastian, Polit, Lélia, Esposito, Michela, Berthelet, Jérémy, Delestré, Laure, Evanno, Emilie, Diop, M’Boyba, Gallais, Isabelle, Aleth, Hanna, Poplineau, Mathilde, Zwart, Wilbert, Rosenbauer, Frank, Rodrigues-Lima, Fernando, Duprez, Estelle, Boeva, Valentina, Guillouf, Christel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371914/
https://www.ncbi.nlm.nih.gov/pubmed/35871293
http://dx.doi.org/10.1093/nar/gkac613

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