Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures

Nucleocapsid protein (N-protein) is required for multiple steps in betacoronaviruses replication. SARS-CoV-2-N-protein condenses with specific viral RNAs at particular temperatures making it a powerful model for deciphering RNA sequence specificity in condensates. We identify two separate and distin...

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Detalles Bibliográficos
Autores principales: Roden, Christine A, Dai, Yifan, Giannetti, Catherine A, Seim, Ian, Lee, Myungwoon, Sealfon, Rachel, McLaughlin, Grace A, Boerneke, Mark A, Iserman, Christiane, Wey, Samuel A, Ekena, Joanne L, Troyanskaya, Olga G, Weeks, Kevin M, You, Lingchong, Chilkoti, Ashutosh, Gladfelter, Amy S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371935/
https://www.ncbi.nlm.nih.gov/pubmed/35871289
http://dx.doi.org/10.1093/nar/gkac596

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