Regulation of NMDA Receptor Signaling at Single Synapses by Human Anti-NMDA Receptor Antibodies

The NMDA receptor (NMDAR) subunit GluN1 is critical for receptor function and plays a pivotal role in synaptic plasticity. Mounting evidence has shown that pathogenic autoantibody targeting of the GluN1 subunit of NMDARs, as in anti-NMDAR encephalitis, leads to altered NMDAR trafficking and synaptic...

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Detalles Bibliográficos
Autores principales: Dean, Charles A., Metzbower, Sarah R., Dessain, Scott K., Blanpied, Thomas A., Benavides, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371948/
https://www.ncbi.nlm.nih.gov/pubmed/35966009
http://dx.doi.org/10.3389/fnmol.2022.940005

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