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Optimal control for the complication of Type 2 diabetes: the role of awareness programs by media and treatment
T2 diabetes is a silent killer and serious public health issue across the world, though awareness of diabetes allows understanding of the causes and prevention of the disease. With this inspiration, we formulate a deterministic model by incorporating awareness and saturated treatment function of the...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371968/ https://www.ncbi.nlm.nih.gov/pubmed/35975278 http://dx.doi.org/10.1007/s40435-022-01013-4 |
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author | Mollah, Saddam Biswas, Santosh |
author_facet | Mollah, Saddam Biswas, Santosh |
author_sort | Mollah, Saddam |
collection | PubMed |
description | T2 diabetes is a silent killer and serious public health issue across the world, though awareness of diabetes allows understanding of the causes and prevention of the disease. With this inspiration, we formulate a deterministic model by incorporating awareness and saturated treatment function of the T2 diabetes model to study the dynamics of the disease. We have carried out thoroughly analysis of the model system, including positivity of solutions, boundedness, equilibrium, and stability analysis. Again, we consider the deterministic model system as an optimal control problem by taking awareness (M) and treatment (u) as time-depended control parameters. The sufficient conditions for optimal control for T2 diabetes are obtained utilizing the Pontryagin’s maximum principle in time-dependent controls to find optimal strategies for disease control. We intended to assess the efficacy and costs of several strategies to determine which is the best cost-effective strategy with the limited resources for treatment. The parameters incident rate ([Formula: see text] ), awareness coefficient (p), media (M), and treatment (u) highly influence the dynamics of T2 diabetes. Numerical simulations suggest that both awareness and treatment controls have a significant impact on the optimal system and are economically feasible to reduce the prevalence of T2 diabetes. |
format | Online Article Text |
id | pubmed-9371968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-93719682022-08-12 Optimal control for the complication of Type 2 diabetes: the role of awareness programs by media and treatment Mollah, Saddam Biswas, Santosh Int J Dyn Control Article T2 diabetes is a silent killer and serious public health issue across the world, though awareness of diabetes allows understanding of the causes and prevention of the disease. With this inspiration, we formulate a deterministic model by incorporating awareness and saturated treatment function of the T2 diabetes model to study the dynamics of the disease. We have carried out thoroughly analysis of the model system, including positivity of solutions, boundedness, equilibrium, and stability analysis. Again, we consider the deterministic model system as an optimal control problem by taking awareness (M) and treatment (u) as time-depended control parameters. The sufficient conditions for optimal control for T2 diabetes are obtained utilizing the Pontryagin’s maximum principle in time-dependent controls to find optimal strategies for disease control. We intended to assess the efficacy and costs of several strategies to determine which is the best cost-effective strategy with the limited resources for treatment. The parameters incident rate ([Formula: see text] ), awareness coefficient (p), media (M), and treatment (u) highly influence the dynamics of T2 diabetes. Numerical simulations suggest that both awareness and treatment controls have a significant impact on the optimal system and are economically feasible to reduce the prevalence of T2 diabetes. Springer Berlin Heidelberg 2022-08-12 2023 /pmc/articles/PMC9371968/ /pubmed/35975278 http://dx.doi.org/10.1007/s40435-022-01013-4 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Mollah, Saddam Biswas, Santosh Optimal control for the complication of Type 2 diabetes: the role of awareness programs by media and treatment |
title | Optimal control for the complication of Type 2 diabetes: the role of awareness programs by media and treatment |
title_full | Optimal control for the complication of Type 2 diabetes: the role of awareness programs by media and treatment |
title_fullStr | Optimal control for the complication of Type 2 diabetes: the role of awareness programs by media and treatment |
title_full_unstemmed | Optimal control for the complication of Type 2 diabetes: the role of awareness programs by media and treatment |
title_short | Optimal control for the complication of Type 2 diabetes: the role of awareness programs by media and treatment |
title_sort | optimal control for the complication of type 2 diabetes: the role of awareness programs by media and treatment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371968/ https://www.ncbi.nlm.nih.gov/pubmed/35975278 http://dx.doi.org/10.1007/s40435-022-01013-4 |
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