Cargando…

Optimal control for the complication of Type 2 diabetes: the role of awareness programs by media and treatment

T2 diabetes is a silent killer and serious public health issue across the world, though awareness of diabetes allows understanding of the causes and prevention of the disease. With this inspiration, we formulate a deterministic model by incorporating awareness and saturated treatment function of the...

Descripción completa

Detalles Bibliográficos
Autores principales: Mollah, Saddam, Biswas, Santosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371968/
https://www.ncbi.nlm.nih.gov/pubmed/35975278
http://dx.doi.org/10.1007/s40435-022-01013-4
_version_ 1784767278223458304
author Mollah, Saddam
Biswas, Santosh
author_facet Mollah, Saddam
Biswas, Santosh
author_sort Mollah, Saddam
collection PubMed
description T2 diabetes is a silent killer and serious public health issue across the world, though awareness of diabetes allows understanding of the causes and prevention of the disease. With this inspiration, we formulate a deterministic model by incorporating awareness and saturated treatment function of the T2 diabetes model to study the dynamics of the disease. We have carried out thoroughly analysis of the model system, including positivity of solutions, boundedness, equilibrium, and stability analysis. Again, we consider the deterministic model system as an optimal control problem by taking awareness (M) and treatment (u) as time-depended control parameters. The sufficient conditions for optimal control for T2 diabetes are obtained utilizing the Pontryagin’s maximum principle in time-dependent controls to find optimal strategies for disease control. We intended to assess the efficacy and costs of several strategies to determine which is the best cost-effective strategy with the limited resources for treatment. The parameters incident rate ([Formula: see text] ), awareness coefficient (p), media (M), and treatment (u) highly influence the dynamics of T2 diabetes. Numerical simulations suggest that both awareness and treatment controls have a significant impact on the optimal system and are economically feasible to reduce the prevalence of T2 diabetes.
format Online
Article
Text
id pubmed-9371968
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-93719682022-08-12 Optimal control for the complication of Type 2 diabetes: the role of awareness programs by media and treatment Mollah, Saddam Biswas, Santosh Int J Dyn Control Article T2 diabetes is a silent killer and serious public health issue across the world, though awareness of diabetes allows understanding of the causes and prevention of the disease. With this inspiration, we formulate a deterministic model by incorporating awareness and saturated treatment function of the T2 diabetes model to study the dynamics of the disease. We have carried out thoroughly analysis of the model system, including positivity of solutions, boundedness, equilibrium, and stability analysis. Again, we consider the deterministic model system as an optimal control problem by taking awareness (M) and treatment (u) as time-depended control parameters. The sufficient conditions for optimal control for T2 diabetes are obtained utilizing the Pontryagin’s maximum principle in time-dependent controls to find optimal strategies for disease control. We intended to assess the efficacy and costs of several strategies to determine which is the best cost-effective strategy with the limited resources for treatment. The parameters incident rate ([Formula: see text] ), awareness coefficient (p), media (M), and treatment (u) highly influence the dynamics of T2 diabetes. Numerical simulations suggest that both awareness and treatment controls have a significant impact on the optimal system and are economically feasible to reduce the prevalence of T2 diabetes. Springer Berlin Heidelberg 2022-08-12 2023 /pmc/articles/PMC9371968/ /pubmed/35975278 http://dx.doi.org/10.1007/s40435-022-01013-4 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Mollah, Saddam
Biswas, Santosh
Optimal control for the complication of Type 2 diabetes: the role of awareness programs by media and treatment
title Optimal control for the complication of Type 2 diabetes: the role of awareness programs by media and treatment
title_full Optimal control for the complication of Type 2 diabetes: the role of awareness programs by media and treatment
title_fullStr Optimal control for the complication of Type 2 diabetes: the role of awareness programs by media and treatment
title_full_unstemmed Optimal control for the complication of Type 2 diabetes: the role of awareness programs by media and treatment
title_short Optimal control for the complication of Type 2 diabetes: the role of awareness programs by media and treatment
title_sort optimal control for the complication of type 2 diabetes: the role of awareness programs by media and treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371968/
https://www.ncbi.nlm.nih.gov/pubmed/35975278
http://dx.doi.org/10.1007/s40435-022-01013-4
work_keys_str_mv AT mollahsaddam optimalcontrolforthecomplicationoftype2diabetestheroleofawarenessprogramsbymediaandtreatment
AT biswassantosh optimalcontrolforthecomplicationoftype2diabetestheroleofawarenessprogramsbymediaandtreatment