A programmable encapsulation system improves delivery of therapeutic bacteria in mice

Living bacteria therapies have been proposed as an alternative approach to treating a broad array of cancers. In this study, we developed a genetically encoded microbial encapsulation system with tunable and dynamic expression of surface capsular polysaccharides that enhances systemic delivery. Base...

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Detalles Bibliográficos
Autores principales: Harimoto, Tetsuhiro, Hahn, Jaeseung, Chen, Yu-Yu, Im, Jongwon, Zhang, Joanna, Hou, Nicholas, Li, Fangda, Coker, Courtney, Gray, Kelsey, Harr, Nicole, Chowdhury, Sreyan, Pu, Kelly, Nimura, Clare, Arpaia, Nicholas, Leong, Kam W., Danino, Tal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371971/
https://www.ncbi.nlm.nih.gov/pubmed/35301496
http://dx.doi.org/10.1038/s41587-022-01244-y

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