Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism

P-Rex (PI(3,4,5)P(3)-dependent Rac exchanger) guanine nucleotide exchange factors potently activate Rho GTPases. P-Rex guanine nucleotide exchange factors are autoinhibited, synergistically activated by Gβγ and PI(3,4,5)P(3) binding and dysregulated in cancer. Here, we use X-ray crystallography, cry...

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Detalles Bibliográficos
Autores principales: Chang, Yong-Gang, Lupton, Christopher J., Bayly-Jones, Charles, Keen, Alastair C., D’Andrea, Laura, Lucato, Christina M., Steele, Joel R., Venugopal, Hari, Schittenhelm, Ralf B., Whisstock, James C., Halls, Michelle L., Ellisdon, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371973/
https://www.ncbi.nlm.nih.gov/pubmed/35864164
http://dx.doi.org/10.1038/s41594-022-00804-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9371973/
https://www.ncbi.nlm.nih.gov/pubmed/35864164
http://dx.doi.org/10.1038/s41594-022-00804-9

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