Ultra-deep sequencing validates safety of CRISPR/Cas9 genome editing in human hematopoietic stem and progenitor cells

As CRISPR-based therapies enter the clinic, evaluation of safety remains a critical and active area of study. Here, we employ a clinical next generation sequencing (NGS) workflow to achieve high sequencing depth and detect ultra-low frequency variants across exons of genes associated with cancer, al...

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Detalles Bibliográficos
Autores principales: Cromer, M. Kyle, Barsan, Valentin V., Jaeger, Erich, Wang, Mengchi, Hampton, Jessica P., Chen, Feng, Kennedy, Drew, Xiao, Jenny, Khrebtukova, Irina, Granat, Ana, Truong, Tiffany, Porteus, Matthew H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372057/
https://www.ncbi.nlm.nih.gov/pubmed/35953477
http://dx.doi.org/10.1038/s41467-022-32233-z

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