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Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2

Glutamate is a pivotal excitatory neurotransmitter in mammalian brains, but excessive glutamate causes numerous neural disorders. Almost all extracellular glutamate is retrieved by the glial transporter, Excitatory Amino Acid Transporter 2 (EAAT2), belonging to the SLC1A family. However, in some can...

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Detalles Bibliográficos
Autores principales:	Kato, Takafumi, Kusakizako, Tsukasa, Jin, Chunhuan, Zhou, Xinyu, Ohgaki, Ryuichi, Quan, LiLi, Xu, Minhui, Okuda, Suguru, Kobayashi, Kan, Yamashita, Keitaro, Nishizawa, Tomohiro, Kanai, Yoshikatsu, Nureki, Osamu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372063/ https://www.ncbi.nlm.nih.gov/pubmed/35953475 http://dx.doi.org/10.1038/s41467-022-32442-6

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