The pre-exposure SARS-CoV-2-specific T cell repertoire determines the quality of the immune response to vaccination

SARS-CoV-2 infection and vaccination generates enormous host-response heterogeneity and an age-dependent loss of immune-response quality. How the pre-exposure T cell repertoire contributes to this heterogeneity is poorly understood. We combined analysis of SARS-CoV-2-specific CD4(+) T cells pre- and...

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Detalles Bibliográficos
Autores principales: Saggau, Carina, Martini, Gabriela Rios, Rosati, Elisa, Meise, Silja, Messner, Berith, Kamps, Ann-Kristin, Bekel, Nicole, Gigla, Johannes, Rose, Ruben, Voß, Mathias, Geisen, Ulf M., Reid, Hayley M., Sümbül, Melike, Tran, Florian, Berner, Dennis K., Khodamoradi, Yascha, Vehreschild, Maria J.G.T., Cornely, Oliver, Koehler, Philipp, Krumbholz, Andi, Fickenscher, Helmut, Kreuzer, Oliver, Schreiber, Claudia, Franke, Andre, Schreiber, Stefan, Hoyer, Bimba, Scheffold, Alexander, Bacher, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372089/
https://www.ncbi.nlm.nih.gov/pubmed/35985324
http://dx.doi.org/10.1016/j.immuni.2022.08.003

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