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Solid-basaloid variant of adenoid cystic carcinoma of the breast with near complete response to neoadjuvant chemotherapy

Breast adenoid cystic carcinoma (AdCC) is a rare subtype of triple negative breast cancer. Two morphologic variants are described, namely classic AdCC (C-AdCC) and solid basaloid (SB-AdCC). Recent studies have shown that the SB-AdCC variant has significantly worse prognosis than C-AdCC. Due to the r...

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Autores principales: Grabenstetter, Anne, Brogi, Edi, Zhang, Hong, Razavi, Pedram, Reis-Filho, Jorge S., VanZee, Kimberly J., Norton, Larry, Wen, Hannah Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372162/
https://www.ncbi.nlm.nih.gov/pubmed/35953528
http://dx.doi.org/10.1038/s41523-022-00469-z
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author Grabenstetter, Anne
Brogi, Edi
Zhang, Hong
Razavi, Pedram
Reis-Filho, Jorge S.
VanZee, Kimberly J.
Norton, Larry
Wen, Hannah Y.
author_facet Grabenstetter, Anne
Brogi, Edi
Zhang, Hong
Razavi, Pedram
Reis-Filho, Jorge S.
VanZee, Kimberly J.
Norton, Larry
Wen, Hannah Y.
author_sort Grabenstetter, Anne
collection PubMed
description Breast adenoid cystic carcinoma (AdCC) is a rare subtype of triple negative breast cancer. Two morphologic variants are described, namely classic AdCC (C-AdCC) and solid basaloid (SB-AdCC). Recent studies have shown that the SB-AdCC variant has significantly worse prognosis than C-AdCC. Due to the rarity of SB-AdCC, no standard recommendations are available for its management. Data on the use and benefit of chemotherapy in patients with SB-AdCC are sparse and the response to neoadjuvant chemotherapy has not been reported. We present the clinical and pathologic findings of a patient with SB-AdCC treated with neoadjuvant chemotherapy who achieved a remarkable pathologic response.
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spelling pubmed-93721622022-08-13 Solid-basaloid variant of adenoid cystic carcinoma of the breast with near complete response to neoadjuvant chemotherapy Grabenstetter, Anne Brogi, Edi Zhang, Hong Razavi, Pedram Reis-Filho, Jorge S. VanZee, Kimberly J. Norton, Larry Wen, Hannah Y. NPJ Breast Cancer Case Report Breast adenoid cystic carcinoma (AdCC) is a rare subtype of triple negative breast cancer. Two morphologic variants are described, namely classic AdCC (C-AdCC) and solid basaloid (SB-AdCC). Recent studies have shown that the SB-AdCC variant has significantly worse prognosis than C-AdCC. Due to the rarity of SB-AdCC, no standard recommendations are available for its management. Data on the use and benefit of chemotherapy in patients with SB-AdCC are sparse and the response to neoadjuvant chemotherapy has not been reported. We present the clinical and pathologic findings of a patient with SB-AdCC treated with neoadjuvant chemotherapy who achieved a remarkable pathologic response. Nature Publishing Group UK 2022-08-11 /pmc/articles/PMC9372162/ /pubmed/35953528 http://dx.doi.org/10.1038/s41523-022-00469-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Case Report
Grabenstetter, Anne
Brogi, Edi
Zhang, Hong
Razavi, Pedram
Reis-Filho, Jorge S.
VanZee, Kimberly J.
Norton, Larry
Wen, Hannah Y.
Solid-basaloid variant of adenoid cystic carcinoma of the breast with near complete response to neoadjuvant chemotherapy
title Solid-basaloid variant of adenoid cystic carcinoma of the breast with near complete response to neoadjuvant chemotherapy
title_full Solid-basaloid variant of adenoid cystic carcinoma of the breast with near complete response to neoadjuvant chemotherapy
title_fullStr Solid-basaloid variant of adenoid cystic carcinoma of the breast with near complete response to neoadjuvant chemotherapy
title_full_unstemmed Solid-basaloid variant of adenoid cystic carcinoma of the breast with near complete response to neoadjuvant chemotherapy
title_short Solid-basaloid variant of adenoid cystic carcinoma of the breast with near complete response to neoadjuvant chemotherapy
title_sort solid-basaloid variant of adenoid cystic carcinoma of the breast with near complete response to neoadjuvant chemotherapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372162/
https://www.ncbi.nlm.nih.gov/pubmed/35953528
http://dx.doi.org/10.1038/s41523-022-00469-z
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