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In silico mutational analysis to identify the role and pathogenicity of BCL-w missense variants
BACKGROUND: Intrinsic pathway of apoptosis is generally mediated by BCL-2 (B cell lymphoma 2) family of proteins; they either induce or inhibit the apoptosis. Overexpression of BCL-2 in cancer cell may lead to delay in apoptosis. BCL-w is the pro-survival member of the BCL-2 family. BCL2L2 gene is p...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Berlin Heidelberg
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372248/ https://www.ncbi.nlm.nih.gov/pubmed/35951173 http://dx.doi.org/10.1186/s43141-022-00389-2 |