A highly stable human single-domain antibody-drug conjugate exhibits superior penetration and treatment of solid tumors

The inefficient tumor penetration of therapeutic antibodies has hampered their effective use in treating solid tumors. Here, we report the identification of a fully human single-domain antibody (UdAb), designated as n501, targeting the oncofetal antigen 5T4. The high-resolution crystal structure ind...

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Detalles Bibliográficos
Autores principales: Wu, Yanling, Li, Quanxiao, Kong, Yu, Wang, Zhi, Lei, Cheng, Li, Ji, Ding, Lulu, Wang, Chunyu, Cheng, Yaping, Wei, Yaozhu, Song, Yuanlin, Yang, Zhenlin, Tu, Chao, Ding, Yu, Ying, Tianlei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372316/
https://www.ncbi.nlm.nih.gov/pubmed/35462042
http://dx.doi.org/10.1016/j.ymthe.2022.04.013

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