Cargando…
Early changes in peripheral blood cytokine levels after the treatment of metastatic hepatic carcinoma with CalliSpheres microspheres drug-eluting beads transcatheter arterial chemoembolization
OBJECTIVE: To observe the early changes in peripheral blood cytokine levels after treatment of metastatic hepatic carcinoma (MHC) with CalliSpheres microspheres drug-eluting beads (DEB) transcatheter arterial chemoembolization (CSM-TACE). METHODS: Twenty-eight patients with refractory MHC who underw...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372401/ https://www.ncbi.nlm.nih.gov/pubmed/35965593 http://dx.doi.org/10.3389/fonc.2022.889312 |
_version_ | 1784767373657505792 |
---|---|
author | Liu, Ying Liu, Song Zhao, Guang Sheng Li, Xiang Gao, Fei Ren, Zhi Zhong Bian, Jie Wu, Jian Lin Zhang, Yue Wei |
author_facet | Liu, Ying Liu, Song Zhao, Guang Sheng Li, Xiang Gao, Fei Ren, Zhi Zhong Bian, Jie Wu, Jian Lin Zhang, Yue Wei |
author_sort | Liu, Ying |
collection | PubMed |
description | OBJECTIVE: To observe the early changes in peripheral blood cytokine levels after treatment of metastatic hepatic carcinoma (MHC) with CalliSpheres microspheres drug-eluting beads (DEB) transcatheter arterial chemoembolization (CSM-TACE). METHODS: Twenty-eight patients with refractory MHC who underwent CSM-TACE were selected prospectively, and 5mL of peripheral blood was collected before CSM-TACE and on the 2nd and 5th day after CSM-TACE. Flow cytometry was used to detect immunological indicators. The early changes in levels of peripheral blood cell inflammatory factors Th1 (interleukin 2 (IL-2), tumor necrosis factor-α (TNF-a), interferon (IFN-r)), Th2 (IL-4, IL-6, IL-10), and Th17 (IL-17A) were observed after CSM-TACE, as well as the ratio of CD4(+)/CD8(+). RESULTS: All the 28 patients underwent CSM-TACE successfully. CT at 4 days after CSM-TACE showed clear outline low-density changes in liver tumors, and honeycomb necrosis was observed in the tumors in some cases. After CSM-TACE, the IL-6 and IL-10 levels were increased and then decreased again. After CSM-TACE, IL-2 showed a trend of transient increase and then decreased again, and the TNF-a level decreased temporarily, and then decreased. After CSM-TACE, the IFN-r level showed a continuous and slowly increasing trend. The IL-17 level showed a continuous downward trend, and the CD4(+)/CD8(+) ratio showed a gradual and continuous upward trend, and there was a negative correlation between them. CONCLUSIONS: There are complex dynamic changes in TH1/Th2 in the early stage of CSM-TACE, and the acute inflammatory response and the enhancement of the body’s immune anti-tumor response coexist. |
format | Online Article Text |
id | pubmed-9372401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93724012022-08-13 Early changes in peripheral blood cytokine levels after the treatment of metastatic hepatic carcinoma with CalliSpheres microspheres drug-eluting beads transcatheter arterial chemoembolization Liu, Ying Liu, Song Zhao, Guang Sheng Li, Xiang Gao, Fei Ren, Zhi Zhong Bian, Jie Wu, Jian Lin Zhang, Yue Wei Front Oncol Oncology OBJECTIVE: To observe the early changes in peripheral blood cytokine levels after treatment of metastatic hepatic carcinoma (MHC) with CalliSpheres microspheres drug-eluting beads (DEB) transcatheter arterial chemoembolization (CSM-TACE). METHODS: Twenty-eight patients with refractory MHC who underwent CSM-TACE were selected prospectively, and 5mL of peripheral blood was collected before CSM-TACE and on the 2nd and 5th day after CSM-TACE. Flow cytometry was used to detect immunological indicators. The early changes in levels of peripheral blood cell inflammatory factors Th1 (interleukin 2 (IL-2), tumor necrosis factor-α (TNF-a), interferon (IFN-r)), Th2 (IL-4, IL-6, IL-10), and Th17 (IL-17A) were observed after CSM-TACE, as well as the ratio of CD4(+)/CD8(+). RESULTS: All the 28 patients underwent CSM-TACE successfully. CT at 4 days after CSM-TACE showed clear outline low-density changes in liver tumors, and honeycomb necrosis was observed in the tumors in some cases. After CSM-TACE, the IL-6 and IL-10 levels were increased and then decreased again. After CSM-TACE, IL-2 showed a trend of transient increase and then decreased again, and the TNF-a level decreased temporarily, and then decreased. After CSM-TACE, the IFN-r level showed a continuous and slowly increasing trend. The IL-17 level showed a continuous downward trend, and the CD4(+)/CD8(+) ratio showed a gradual and continuous upward trend, and there was a negative correlation between them. CONCLUSIONS: There are complex dynamic changes in TH1/Th2 in the early stage of CSM-TACE, and the acute inflammatory response and the enhancement of the body’s immune anti-tumor response coexist. Frontiers Media S.A. 2022-07-29 /pmc/articles/PMC9372401/ /pubmed/35965593 http://dx.doi.org/10.3389/fonc.2022.889312 Text en Copyright © 2022 Liu, Liu, Zhao, Li, Gao, Ren, Bian, Wu and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Liu, Ying Liu, Song Zhao, Guang Sheng Li, Xiang Gao, Fei Ren, Zhi Zhong Bian, Jie Wu, Jian Lin Zhang, Yue Wei Early changes in peripheral blood cytokine levels after the treatment of metastatic hepatic carcinoma with CalliSpheres microspheres drug-eluting beads transcatheter arterial chemoembolization |
title | Early changes in peripheral blood cytokine levels after the treatment of metastatic hepatic carcinoma with CalliSpheres microspheres drug-eluting beads transcatheter arterial chemoembolization |
title_full | Early changes in peripheral blood cytokine levels after the treatment of metastatic hepatic carcinoma with CalliSpheres microspheres drug-eluting beads transcatheter arterial chemoembolization |
title_fullStr | Early changes in peripheral blood cytokine levels after the treatment of metastatic hepatic carcinoma with CalliSpheres microspheres drug-eluting beads transcatheter arterial chemoembolization |
title_full_unstemmed | Early changes in peripheral blood cytokine levels after the treatment of metastatic hepatic carcinoma with CalliSpheres microspheres drug-eluting beads transcatheter arterial chemoembolization |
title_short | Early changes in peripheral blood cytokine levels after the treatment of metastatic hepatic carcinoma with CalliSpheres microspheres drug-eluting beads transcatheter arterial chemoembolization |
title_sort | early changes in peripheral blood cytokine levels after the treatment of metastatic hepatic carcinoma with callispheres microspheres drug-eluting beads transcatheter arterial chemoembolization |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372401/ https://www.ncbi.nlm.nih.gov/pubmed/35965593 http://dx.doi.org/10.3389/fonc.2022.889312 |
work_keys_str_mv | AT liuying earlychangesinperipheralbloodcytokinelevelsafterthetreatmentofmetastatichepaticcarcinomawithcallispheresmicrospheresdrugelutingbeadstranscatheterarterialchemoembolization AT liusong earlychangesinperipheralbloodcytokinelevelsafterthetreatmentofmetastatichepaticcarcinomawithcallispheresmicrospheresdrugelutingbeadstranscatheterarterialchemoembolization AT zhaoguangsheng earlychangesinperipheralbloodcytokinelevelsafterthetreatmentofmetastatichepaticcarcinomawithcallispheresmicrospheresdrugelutingbeadstranscatheterarterialchemoembolization AT lixiang earlychangesinperipheralbloodcytokinelevelsafterthetreatmentofmetastatichepaticcarcinomawithcallispheresmicrospheresdrugelutingbeadstranscatheterarterialchemoembolization AT gaofei earlychangesinperipheralbloodcytokinelevelsafterthetreatmentofmetastatichepaticcarcinomawithcallispheresmicrospheresdrugelutingbeadstranscatheterarterialchemoembolization AT renzhizhong earlychangesinperipheralbloodcytokinelevelsafterthetreatmentofmetastatichepaticcarcinomawithcallispheresmicrospheresdrugelutingbeadstranscatheterarterialchemoembolization AT bianjie earlychangesinperipheralbloodcytokinelevelsafterthetreatmentofmetastatichepaticcarcinomawithcallispheresmicrospheresdrugelutingbeadstranscatheterarterialchemoembolization AT wujianlin earlychangesinperipheralbloodcytokinelevelsafterthetreatmentofmetastatichepaticcarcinomawithcallispheresmicrospheresdrugelutingbeadstranscatheterarterialchemoembolization AT zhangyuewei earlychangesinperipheralbloodcytokinelevelsafterthetreatmentofmetastatichepaticcarcinomawithcallispheresmicrospheresdrugelutingbeadstranscatheterarterialchemoembolization |