Cardiac sodium channel inhibition by lamotrigine: In vitro characterization and clinical implications

Lamotrigine, approved for use as an antiseizure medication as well as the treatment of bipolar disorder, inhibits sodium channels in the brain to reduce repetitive neuronal firing and pathological release of glutamate. The shared homology of sodium channels and lack of selectivity associated with ch...

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Detalles Bibliográficos
Autores principales: Ingleby‐Talecki, Lindsey, van Dijkman, Sven C., Oosterholt, Sean P., Della Pasqua, Oscar, Winter, Christina, Cunnington, Marianne, Rebar, Linda, Forero‐Schwanhaeuser, Sergio, Patel, Vickas, Cooper, James A., Bahinski, Anthony, Chaudhary, Khuram W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372421/
https://www.ncbi.nlm.nih.gov/pubmed/35579204
http://dx.doi.org/10.1111/cts.13311

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