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A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model

Curcumin has been reported to improve or prevent movement disorders in Parkinson’s disease (PD); however, its low bioavailability is the biggest obstacle to its application. To optimize the limited efficacy of curcumin and to improve its protective effects against PD, we prepared and tested a novel...

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Autores principales: Geng, Xiwen, Zhang, Hao, Hu, Minghui, Liu, Xiaoyu, Han, Min, Xie, Jinlu, Li, Zifa, Zhao, Feng, Liu, Wei, Wei, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372469/
https://www.ncbi.nlm.nih.gov/pubmed/35966793
http://dx.doi.org/10.3389/fnagi.2022.984895
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author Geng, Xiwen
Zhang, Hao
Hu, Minghui
Liu, Xiaoyu
Han, Min
Xie, Jinlu
Li, Zifa
Zhao, Feng
Liu, Wei
Wei, Sheng
author_facet Geng, Xiwen
Zhang, Hao
Hu, Minghui
Liu, Xiaoyu
Han, Min
Xie, Jinlu
Li, Zifa
Zhao, Feng
Liu, Wei
Wei, Sheng
author_sort Geng, Xiwen
collection PubMed
description Curcumin has been reported to improve or prevent movement disorders in Parkinson’s disease (PD); however, its low bioavailability is the biggest obstacle to its application. To optimize the limited efficacy of curcumin and to improve its protective effects against PD, we prepared and tested a novel curcumin oil solution. In vivo imaging was used to confirm that the curcumin oil solution has higher bioavailability than curcumin alone. To test its motor effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced movement disorders, behavioral tests, including the open-field test, pole test, rotarod test, and automated gait analysis were used. Finally, pathological evaluation using immunohistochemistry and western blotting analysis was done. Encouragingly, the behavioral test findings exhibited a better protective effect against MPTP-induced movement disorders. In addition, it had a greater protective effect on dopaminergic neurons in the compact part of the substantia nigra along with the PD process according to pathological evaluation. This novel curcumin oil solution may provide a new choice for PD prevention as a dietary supplement or clinically assisted treatment based on its better bioavailability and efficiency.
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spelling pubmed-93724692022-08-13 A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model Geng, Xiwen Zhang, Hao Hu, Minghui Liu, Xiaoyu Han, Min Xie, Jinlu Li, Zifa Zhao, Feng Liu, Wei Wei, Sheng Front Aging Neurosci Aging Neuroscience Curcumin has been reported to improve or prevent movement disorders in Parkinson’s disease (PD); however, its low bioavailability is the biggest obstacle to its application. To optimize the limited efficacy of curcumin and to improve its protective effects against PD, we prepared and tested a novel curcumin oil solution. In vivo imaging was used to confirm that the curcumin oil solution has higher bioavailability than curcumin alone. To test its motor effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced movement disorders, behavioral tests, including the open-field test, pole test, rotarod test, and automated gait analysis were used. Finally, pathological evaluation using immunohistochemistry and western blotting analysis was done. Encouragingly, the behavioral test findings exhibited a better protective effect against MPTP-induced movement disorders. In addition, it had a greater protective effect on dopaminergic neurons in the compact part of the substantia nigra along with the PD process according to pathological evaluation. This novel curcumin oil solution may provide a new choice for PD prevention as a dietary supplement or clinically assisted treatment based on its better bioavailability and efficiency. Frontiers Media S.A. 2022-07-29 /pmc/articles/PMC9372469/ /pubmed/35966793 http://dx.doi.org/10.3389/fnagi.2022.984895 Text en Copyright © 2022 Geng, Zhang, Hu, Liu, Han, Xie, Li, Zhao, Liu and Wei. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Geng, Xiwen
Zhang, Hao
Hu, Minghui
Liu, Xiaoyu
Han, Min
Xie, Jinlu
Li, Zifa
Zhao, Feng
Liu, Wei
Wei, Sheng
A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model
title A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model
title_full A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model
title_fullStr A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model
title_full_unstemmed A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model
title_short A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model
title_sort novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a parkinson’s disease mouse model
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372469/
https://www.ncbi.nlm.nih.gov/pubmed/35966793
http://dx.doi.org/10.3389/fnagi.2022.984895
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