Cargando…
A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model
Curcumin has been reported to improve or prevent movement disorders in Parkinson’s disease (PD); however, its low bioavailability is the biggest obstacle to its application. To optimize the limited efficacy of curcumin and to improve its protective effects against PD, we prepared and tested a novel...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372469/ https://www.ncbi.nlm.nih.gov/pubmed/35966793 http://dx.doi.org/10.3389/fnagi.2022.984895 |
_version_ | 1784767390364467200 |
---|---|
author | Geng, Xiwen Zhang, Hao Hu, Minghui Liu, Xiaoyu Han, Min Xie, Jinlu Li, Zifa Zhao, Feng Liu, Wei Wei, Sheng |
author_facet | Geng, Xiwen Zhang, Hao Hu, Minghui Liu, Xiaoyu Han, Min Xie, Jinlu Li, Zifa Zhao, Feng Liu, Wei Wei, Sheng |
author_sort | Geng, Xiwen |
collection | PubMed |
description | Curcumin has been reported to improve or prevent movement disorders in Parkinson’s disease (PD); however, its low bioavailability is the biggest obstacle to its application. To optimize the limited efficacy of curcumin and to improve its protective effects against PD, we prepared and tested a novel curcumin oil solution. In vivo imaging was used to confirm that the curcumin oil solution has higher bioavailability than curcumin alone. To test its motor effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced movement disorders, behavioral tests, including the open-field test, pole test, rotarod test, and automated gait analysis were used. Finally, pathological evaluation using immunohistochemistry and western blotting analysis was done. Encouragingly, the behavioral test findings exhibited a better protective effect against MPTP-induced movement disorders. In addition, it had a greater protective effect on dopaminergic neurons in the compact part of the substantia nigra along with the PD process according to pathological evaluation. This novel curcumin oil solution may provide a new choice for PD prevention as a dietary supplement or clinically assisted treatment based on its better bioavailability and efficiency. |
format | Online Article Text |
id | pubmed-9372469 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93724692022-08-13 A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model Geng, Xiwen Zhang, Hao Hu, Minghui Liu, Xiaoyu Han, Min Xie, Jinlu Li, Zifa Zhao, Feng Liu, Wei Wei, Sheng Front Aging Neurosci Aging Neuroscience Curcumin has been reported to improve or prevent movement disorders in Parkinson’s disease (PD); however, its low bioavailability is the biggest obstacle to its application. To optimize the limited efficacy of curcumin and to improve its protective effects against PD, we prepared and tested a novel curcumin oil solution. In vivo imaging was used to confirm that the curcumin oil solution has higher bioavailability than curcumin alone. To test its motor effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced movement disorders, behavioral tests, including the open-field test, pole test, rotarod test, and automated gait analysis were used. Finally, pathological evaluation using immunohistochemistry and western blotting analysis was done. Encouragingly, the behavioral test findings exhibited a better protective effect against MPTP-induced movement disorders. In addition, it had a greater protective effect on dopaminergic neurons in the compact part of the substantia nigra along with the PD process according to pathological evaluation. This novel curcumin oil solution may provide a new choice for PD prevention as a dietary supplement or clinically assisted treatment based on its better bioavailability and efficiency. Frontiers Media S.A. 2022-07-29 /pmc/articles/PMC9372469/ /pubmed/35966793 http://dx.doi.org/10.3389/fnagi.2022.984895 Text en Copyright © 2022 Geng, Zhang, Hu, Liu, Han, Xie, Li, Zhao, Liu and Wei. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Aging Neuroscience Geng, Xiwen Zhang, Hao Hu, Minghui Liu, Xiaoyu Han, Min Xie, Jinlu Li, Zifa Zhao, Feng Liu, Wei Wei, Sheng A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model |
title | A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model |
title_full | A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model |
title_fullStr | A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model |
title_full_unstemmed | A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model |
title_short | A novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a Parkinson’s disease mouse model |
title_sort | novel curcumin oil solution can better alleviate the motor activity defects and neuropathological damage of a parkinson’s disease mouse model |
topic | Aging Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372469/ https://www.ncbi.nlm.nih.gov/pubmed/35966793 http://dx.doi.org/10.3389/fnagi.2022.984895 |
work_keys_str_mv | AT gengxiwen anovelcurcuminoilsolutioncanbetteralleviatethemotoractivitydefectsandneuropathologicaldamageofaparkinsonsdiseasemousemodel AT zhanghao anovelcurcuminoilsolutioncanbetteralleviatethemotoractivitydefectsandneuropathologicaldamageofaparkinsonsdiseasemousemodel AT huminghui anovelcurcuminoilsolutioncanbetteralleviatethemotoractivitydefectsandneuropathologicaldamageofaparkinsonsdiseasemousemodel AT liuxiaoyu anovelcurcuminoilsolutioncanbetteralleviatethemotoractivitydefectsandneuropathologicaldamageofaparkinsonsdiseasemousemodel AT hanmin anovelcurcuminoilsolutioncanbetteralleviatethemotoractivitydefectsandneuropathologicaldamageofaparkinsonsdiseasemousemodel AT xiejinlu anovelcurcuminoilsolutioncanbetteralleviatethemotoractivitydefectsandneuropathologicaldamageofaparkinsonsdiseasemousemodel AT lizifa anovelcurcuminoilsolutioncanbetteralleviatethemotoractivitydefectsandneuropathologicaldamageofaparkinsonsdiseasemousemodel AT zhaofeng anovelcurcuminoilsolutioncanbetteralleviatethemotoractivitydefectsandneuropathologicaldamageofaparkinsonsdiseasemousemodel AT liuwei anovelcurcuminoilsolutioncanbetteralleviatethemotoractivitydefectsandneuropathologicaldamageofaparkinsonsdiseasemousemodel AT weisheng anovelcurcuminoilsolutioncanbetteralleviatethemotoractivitydefectsandneuropathologicaldamageofaparkinsonsdiseasemousemodel AT gengxiwen novelcurcuminoilsolutioncanbetteralleviatethemotoractivitydefectsandneuropathologicaldamageofaparkinsonsdiseasemousemodel AT zhanghao novelcurcuminoilsolutioncanbetteralleviatethemotoractivitydefectsandneuropathologicaldamageofaparkinsonsdiseasemousemodel AT huminghui novelcurcuminoilsolutioncanbetteralleviatethemotoractivitydefectsandneuropathologicaldamageofaparkinsonsdiseasemousemodel AT liuxiaoyu novelcurcuminoilsolutioncanbetteralleviatethemotoractivitydefectsandneuropathologicaldamageofaparkinsonsdiseasemousemodel AT hanmin novelcurcuminoilsolutioncanbetteralleviatethemotoractivitydefectsandneuropathologicaldamageofaparkinsonsdiseasemousemodel AT xiejinlu novelcurcuminoilsolutioncanbetteralleviatethemotoractivitydefectsandneuropathologicaldamageofaparkinsonsdiseasemousemodel AT lizifa novelcurcuminoilsolutioncanbetteralleviatethemotoractivitydefectsandneuropathologicaldamageofaparkinsonsdiseasemousemodel AT zhaofeng novelcurcuminoilsolutioncanbetteralleviatethemotoractivitydefectsandneuropathologicaldamageofaparkinsonsdiseasemousemodel AT liuwei novelcurcuminoilsolutioncanbetteralleviatethemotoractivitydefectsandneuropathologicaldamageofaparkinsonsdiseasemousemodel AT weisheng novelcurcuminoilsolutioncanbetteralleviatethemotoractivitydefectsandneuropathologicaldamageofaparkinsonsdiseasemousemodel |