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Potential health benefits of lowering gas production and bifidogenic effect of the blends of polydextrose with inulin in a human gut model

Polydextrose is a nutrient supplement, which is widely applied in the food industry. The use of polydextrose in combination with prebiotics and probiotics has recently increased, whereas the fermentation properties of its blend have not yet been fully revealed. We evaluated the metabolic profile of...

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Autores principales: Zhu, Liying, Guo, Fangjie, Guo, Zeyu, Chen, Xiaoqiang, Qian, Xiaoguo, Li, Xianglong, Li, Xiaoqiong, Li, Jinjun, Wang, Xin, Jia, Weiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372503/
https://www.ncbi.nlm.nih.gov/pubmed/35967807
http://dx.doi.org/10.3389/fnut.2022.934621
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author Zhu, Liying
Guo, Fangjie
Guo, Zeyu
Chen, Xiaoqiang
Qian, Xiaoguo
Li, Xianglong
Li, Xiaoqiong
Li, Jinjun
Wang, Xin
Jia, Weiguo
author_facet Zhu, Liying
Guo, Fangjie
Guo, Zeyu
Chen, Xiaoqiang
Qian, Xiaoguo
Li, Xianglong
Li, Xiaoqiong
Li, Jinjun
Wang, Xin
Jia, Weiguo
author_sort Zhu, Liying
collection PubMed
description Polydextrose is a nutrient supplement, which is widely applied in the food industry. The use of polydextrose in combination with prebiotics and probiotics has recently increased, whereas the fermentation properties of its blend have not yet been fully revealed. We evaluated the metabolic profile of polydextrose, inulin, and their blends by a batch in vitro fermentation of fifteen human fecal inocula. After 24 h of fermentation, polydextrose increased the production of gas, ammonia, and several short chain fatty acids, including propionate and butyrate, when compared to its blends, inulin, and fructo-oligosaccharides. Furthermore, polydextrose had the slowest degradation rate of all the carbohydrates tested, consistent with its partial fermentation in the distal colon. The 16S rRNA gene sequencing analysis of the gut microbiome exhibited significantly increased relative abundance of Clostridium_XVIII, Megamonas, Mitsuokella, and Erysipelotrichaceae_incertae_sedis in polydextrose compared to other carbohydrates. On the other hand, the blends of polydextrose and inulin (1:1 or 2:1) showed reduced gas production and similar bifidogenicity to inulin alone. The blends not only had similar alpha-diversity and PCoA to inulin but also had a similar abundance of beneficial bacteria, such as Faecalibacterium and Roseburia, suggesting potential health benefits. Also their low gas production was likely due to the abundance of Faecalibacterium and Anaerostipes, which were negatively correlated with gas production. Additionally, our in vitro fermentation model shows advantages in the large-scale assessment of fermentation performance.
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spelling pubmed-93725032022-08-13 Potential health benefits of lowering gas production and bifidogenic effect of the blends of polydextrose with inulin in a human gut model Zhu, Liying Guo, Fangjie Guo, Zeyu Chen, Xiaoqiang Qian, Xiaoguo Li, Xianglong Li, Xiaoqiong Li, Jinjun Wang, Xin Jia, Weiguo Front Nutr Nutrition Polydextrose is a nutrient supplement, which is widely applied in the food industry. The use of polydextrose in combination with prebiotics and probiotics has recently increased, whereas the fermentation properties of its blend have not yet been fully revealed. We evaluated the metabolic profile of polydextrose, inulin, and their blends by a batch in vitro fermentation of fifteen human fecal inocula. After 24 h of fermentation, polydextrose increased the production of gas, ammonia, and several short chain fatty acids, including propionate and butyrate, when compared to its blends, inulin, and fructo-oligosaccharides. Furthermore, polydextrose had the slowest degradation rate of all the carbohydrates tested, consistent with its partial fermentation in the distal colon. The 16S rRNA gene sequencing analysis of the gut microbiome exhibited significantly increased relative abundance of Clostridium_XVIII, Megamonas, Mitsuokella, and Erysipelotrichaceae_incertae_sedis in polydextrose compared to other carbohydrates. On the other hand, the blends of polydextrose and inulin (1:1 or 2:1) showed reduced gas production and similar bifidogenicity to inulin alone. The blends not only had similar alpha-diversity and PCoA to inulin but also had a similar abundance of beneficial bacteria, such as Faecalibacterium and Roseburia, suggesting potential health benefits. Also their low gas production was likely due to the abundance of Faecalibacterium and Anaerostipes, which were negatively correlated with gas production. Additionally, our in vitro fermentation model shows advantages in the large-scale assessment of fermentation performance. Frontiers Media S.A. 2022-07-29 /pmc/articles/PMC9372503/ /pubmed/35967807 http://dx.doi.org/10.3389/fnut.2022.934621 Text en Copyright © 2022 Zhu, Guo, Guo, Chen, Qian, Li, Li, Li, Wang and Jia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Zhu, Liying
Guo, Fangjie
Guo, Zeyu
Chen, Xiaoqiang
Qian, Xiaoguo
Li, Xianglong
Li, Xiaoqiong
Li, Jinjun
Wang, Xin
Jia, Weiguo
Potential health benefits of lowering gas production and bifidogenic effect of the blends of polydextrose with inulin in a human gut model
title Potential health benefits of lowering gas production and bifidogenic effect of the blends of polydextrose with inulin in a human gut model
title_full Potential health benefits of lowering gas production and bifidogenic effect of the blends of polydextrose with inulin in a human gut model
title_fullStr Potential health benefits of lowering gas production and bifidogenic effect of the blends of polydextrose with inulin in a human gut model
title_full_unstemmed Potential health benefits of lowering gas production and bifidogenic effect of the blends of polydextrose with inulin in a human gut model
title_short Potential health benefits of lowering gas production and bifidogenic effect of the blends of polydextrose with inulin in a human gut model
title_sort potential health benefits of lowering gas production and bifidogenic effect of the blends of polydextrose with inulin in a human gut model
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372503/
https://www.ncbi.nlm.nih.gov/pubmed/35967807
http://dx.doi.org/10.3389/fnut.2022.934621
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