Rationale and design of a multicenter, double-blinded, randomized, placebo-controlled trial to investigate the effects of naldemedine on opioid-induced constipation for patients with cancer pain: A study protocol

BACKGROUND: It is unclear which laxatives are appropriate to prevent opioid-induced constipation (OIC). This study will evaluate whether prophylactic use of naldemedine prevents OIC in patients with cancer who start opioid administration. METHODS: This study is a multicenter, double-blinded, randomi...

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Detalles Bibliográficos
Autores principales: Higashibata, Takahiro, Hamano, Jun, Kessoku, Takaomi, Kajiura, Shinya, Hirakawa, Mami, Horie, Yoshiki, Shimizu, Masaki, Oyamada, Shunsuke, Ariyoshi, Keisuke, Kihara, Kota, Yamanaka, Yohei, Konishi, Kumi, Doki, Kosuke, Takashima, Yasuyuki, Horiuchi, Manabu, Homma, Masato, Yamada, Takeshi, Yamamoto, Yoshiyuki, Moriwaki, Toshikazu, Morita, Tatsuya, Nakajima, Atsushi, Nagaoka, Hiroka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372594/
https://www.ncbi.nlm.nih.gov/pubmed/35967517
http://dx.doi.org/10.1016/j.conctc.2022.100967

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