Characterization and pathogenicity of infectious bursal disease virus in Southern China

Infectious bursal disease virus (IBDV) is a widespread pathogen that induces immunosuppression in 3 to 6-wk-old chickens, casuing great threaten to the poultry industry worldwide. Previously, the very virulent IBDV (vvIBDV) was mainly prevalent in China. In recent years, the novel variant IBDV (nvIB...

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Autores principales: Chen, Zixian, Lian, Jiamin, Liang, Zhishan, Leng, Mei, Lin, Wencheng, Chen, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
IMMUNOLOGY, HEALTH AND DISEASE
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372626/
https://www.ncbi.nlm.nih.gov/pubmed/35952600
http://dx.doi.org/10.1016/j.psj.2022.102018
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author Chen, Zixian
Lian, Jiamin
Liang, Zhishan
Leng, Mei
Lin, Wencheng
Chen, Feng
author_facet Chen, Zixian
Lian, Jiamin
Liang, Zhishan
Leng, Mei
Lin, Wencheng
Chen, Feng
author_sort Chen, Zixian
collection PubMed
description Infectious bursal disease virus (IBDV) is a widespread pathogen that induces immunosuppression in 3 to 6-wk-old chickens, casuing great threaten to the poultry industry worldwide. Previously, the very virulent IBDV (vvIBDV) was mainly prevalent in China. In recent years, the novel variant IBDV (nvIBDV) occurred in China. In this study, we isolated 30 IBDV strains of IBDV from vaccinated chicken flocks in 8 provinces of southern China. Among these isolates, vvIBDV group (13/30) and nvIBDV group (17/30) were identified according to the genome sequencing and phylogenic analysis. Moreover, HB2021-5 and GD2021-17 have pathologic characteristics with severe bursal lesions, as evidenced by necrosis, depletion of lymphocytes, and follicle atrophy. Our findings provide an important reference for understanding the epidemiological status and the evolution of IBDV.
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spelling pubmed-93726262022-08-13 Characterization and pathogenicity of infectious bursal disease virus in Southern China Chen, Zixian Lian, Jiamin Liang, Zhishan Leng, Mei Lin, Wencheng Chen, Feng Poult Sci IMMUNOLOGY, HEALTH AND DISEASE Infectious bursal disease virus (IBDV) is a widespread pathogen that induces immunosuppression in 3 to 6-wk-old chickens, casuing great threaten to the poultry industry worldwide. Previously, the very virulent IBDV (vvIBDV) was mainly prevalent in China. In recent years, the novel variant IBDV (nvIBDV) occurred in China. In this study, we isolated 30 IBDV strains of IBDV from vaccinated chicken flocks in 8 provinces of southern China. Among these isolates, vvIBDV group (13/30) and nvIBDV group (17/30) were identified according to the genome sequencing and phylogenic analysis. Moreover, HB2021-5 and GD2021-17 have pathologic characteristics with severe bursal lesions, as evidenced by necrosis, depletion of lymphocytes, and follicle atrophy. Our findings provide an important reference for understanding the epidemiological status and the evolution of IBDV. Elsevier 2022-06-20 /pmc/articles/PMC9372626/ /pubmed/35952600 http://dx.doi.org/10.1016/j.psj.2022.102018 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle IMMUNOLOGY, HEALTH AND DISEASE
Chen, Zixian
Lian, Jiamin
Liang, Zhishan
Leng, Mei
Lin, Wencheng
Chen, Feng
Characterization and pathogenicity of infectious bursal disease virus in Southern China
title Characterization and pathogenicity of infectious bursal disease virus in Southern China
title_full Characterization and pathogenicity of infectious bursal disease virus in Southern China
title_fullStr Characterization and pathogenicity of infectious bursal disease virus in Southern China
title_full_unstemmed Characterization and pathogenicity of infectious bursal disease virus in Southern China
title_short Characterization and pathogenicity of infectious bursal disease virus in Southern China
title_sort characterization and pathogenicity of infectious bursal disease virus in southern china
topic IMMUNOLOGY, HEALTH AND DISEASE
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372626/
https://www.ncbi.nlm.nih.gov/pubmed/35952600
http://dx.doi.org/10.1016/j.psj.2022.102018
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