Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1

Trio is a large and highly conserved metazoan signaling scaffold that contains two Dbl family guanine nucleotide exchange factor (GEF) modules, TrioN and TrioC, selective for Rac and RhoA GTPases, respectively. The GEF activities of TrioN and TrioC are implicated in several cancers, especially uveal...

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Detalles Bibliográficos
Autores principales: Bandekar, Sumit J., Chen, Chun-Liang, Ravala, Sandeep K., Cash, Jennifer N., Avramova, Larisa V., Zhalnina, Mariya V., Gutkind, J. Silvio, Li, Sheng, Tesmer, John J.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372627/
https://www.ncbi.nlm.nih.gov/pubmed/35779635
http://dx.doi.org/10.1016/j.jbc.2022.102209

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