Malignant juxtaglomerular cell tumor

Juxtaglomerular cell tumors (JGCTs) are rare, typically benign neoplasms; only rare cases are clinically or histologically malignant. We herein report the histologic, immunophenotypic, and molecular features of a clinically unsuspected, diagnostically challenging case of malignant JGCT in a 23-year-...

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Detalles Bibliográficos
Autores principales: Geisler, Daniel, Almutairi, Fawaz, John, Ivy, Quiroga-Garza, Gabriela, Yu, Michelle, Seethala, Raja, Bastacky, Sheldon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372647/
https://www.ncbi.nlm.nih.gov/pubmed/35968528
http://dx.doi.org/10.1016/j.eucr.2022.102176
Descripción
Sumario:Juxtaglomerular cell tumors (JGCTs) are rare, typically benign neoplasms; only rare cases are clinically or histologically malignant. We herein report the histologic, immunophenotypic, and molecular features of a clinically unsuspected, diagnostically challenging case of malignant JGCT in a 23-year-old man. The diagnosis is confirmed with electron microscopy. The case is notable for its marked mitotic activity, which has not been previously reported in JGCTs, and novel finding of GATA3 immunohistochemical positivity.

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