Malignant juxtaglomerular cell tumor

Juxtaglomerular cell tumors (JGCTs) are rare, typically benign neoplasms; only rare cases are clinically or histologically malignant. We herein report the histologic, immunophenotypic, and molecular features of a clinically unsuspected, diagnostically challenging case of malignant JGCT in a 23-year-...

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Autores principales: Geisler, Daniel, Almutairi, Fawaz, John, Ivy, Quiroga-Garza, Gabriela, Yu, Michelle, Seethala, Raja, Bastacky, Sheldon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372647/
https://www.ncbi.nlm.nih.gov/pubmed/35968528
http://dx.doi.org/10.1016/j.eucr.2022.102176
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author Geisler, Daniel
Almutairi, Fawaz
John, Ivy
Quiroga-Garza, Gabriela
Yu, Michelle
Seethala, Raja
Bastacky, Sheldon
author_facet Geisler, Daniel
Almutairi, Fawaz
John, Ivy
Quiroga-Garza, Gabriela
Yu, Michelle
Seethala, Raja
Bastacky, Sheldon
author_sort Geisler, Daniel
collection PubMed
description Juxtaglomerular cell tumors (JGCTs) are rare, typically benign neoplasms; only rare cases are clinically or histologically malignant. We herein report the histologic, immunophenotypic, and molecular features of a clinically unsuspected, diagnostically challenging case of malignant JGCT in a 23-year-old man. The diagnosis is confirmed with electron microscopy. The case is notable for its marked mitotic activity, which has not been previously reported in JGCTs, and novel finding of GATA3 immunohistochemical positivity.
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spelling pubmed-93726472022-08-13 Malignant juxtaglomerular cell tumor Geisler, Daniel Almutairi, Fawaz John, Ivy Quiroga-Garza, Gabriela Yu, Michelle Seethala, Raja Bastacky, Sheldon Urol Case Rep Oncology Juxtaglomerular cell tumors (JGCTs) are rare, typically benign neoplasms; only rare cases are clinically or histologically malignant. We herein report the histologic, immunophenotypic, and molecular features of a clinically unsuspected, diagnostically challenging case of malignant JGCT in a 23-year-old man. The diagnosis is confirmed with electron microscopy. The case is notable for its marked mitotic activity, which has not been previously reported in JGCTs, and novel finding of GATA3 immunohistochemical positivity. Elsevier 2022-07-31 /pmc/articles/PMC9372647/ /pubmed/35968528 http://dx.doi.org/10.1016/j.eucr.2022.102176 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Oncology
Geisler, Daniel
Almutairi, Fawaz
John, Ivy
Quiroga-Garza, Gabriela
Yu, Michelle
Seethala, Raja
Bastacky, Sheldon
Malignant juxtaglomerular cell tumor
title Malignant juxtaglomerular cell tumor
title_full Malignant juxtaglomerular cell tumor
title_fullStr Malignant juxtaglomerular cell tumor
title_full_unstemmed Malignant juxtaglomerular cell tumor
title_short Malignant juxtaglomerular cell tumor
title_sort malignant juxtaglomerular cell tumor
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372647/
https://www.ncbi.nlm.nih.gov/pubmed/35968528
http://dx.doi.org/10.1016/j.eucr.2022.102176
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AT yumichelle malignantjuxtaglomerularcelltumor
AT seethalaraja malignantjuxtaglomerularcelltumor
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