The ciliary protein Spef2 stimulates acinar Ampkα/Sirt1 signaling and ameliorates acute pancreatitis and associated lung injury

BACKGROUND: Pancreatic acinar cells are susceptible to nuclear factor kappa B (NF-κB)-mediated inflammation and resulting cell necrosis during early acute pancreatitis. As adenosine monophosphate-activated protein kinase alpha (Ampkα)/sirtuin 1 (Sirt1) pathway activity attenuates NF-κB activity, we...

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Detalles Bibliográficos
Autores principales: Zhang, Chun, Guo, Deng-Fang, Lv, Gui-Fang, Zhang, Dai-Chang, Lin, Feng, Liu, Jia-Bin, Lin, Jian-Yuan, Xiao, De-Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372661/
https://www.ncbi.nlm.nih.gov/pubmed/35965828
http://dx.doi.org/10.21037/atm-22-3118

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