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A case of acute focal bacterial nephritis caused by methicillin-resistant Staphylococcus saprophyticus in a 13-year-old adolescent girl treated with daptomycin

Staphylococcus saprophyticus is a gram-positive, coagulase-negative member of the Staphylococcus genus and is second only to Escherichia coli as a cause of urinary tract infections in the young female population. S. saprophyticus usually has good susceptibility to drugs commonly used to treat urinar...

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Autores principales: Kinoshita, Teruhisa, Sahara, Shoko, Mihara, Yuka, Asai, Yumiko, Sato, Hiroko, Sakakibara, Takashi, Takimoto, Norio, Oka, Keisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372729/
https://www.ncbi.nlm.nih.gov/pubmed/35966278
http://dx.doi.org/10.1016/j.idcr.2022.e01594
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author Kinoshita, Teruhisa
Sahara, Shoko
Mihara, Yuka
Asai, Yumiko
Sato, Hiroko
Sakakibara, Takashi
Takimoto, Norio
Oka, Keisuke
author_facet Kinoshita, Teruhisa
Sahara, Shoko
Mihara, Yuka
Asai, Yumiko
Sato, Hiroko
Sakakibara, Takashi
Takimoto, Norio
Oka, Keisuke
author_sort Kinoshita, Teruhisa
collection PubMed
description Staphylococcus saprophyticus is a gram-positive, coagulase-negative member of the Staphylococcus genus and is second only to Escherichia coli as a cause of urinary tract infections in the young female population. S. saprophyticus usually has good susceptibility to drugs commonly used to treat urinary tract infections, but it is often methicillin-resistant. Here we report a case of acute focal bacterial nephritis in a 13-year-old female patient caused by methicillin-resistant S. saprophyticus and treated with daptomycin (DAP). The patient had a history of unilateral hearing loss and presented to her previous physician with a 3-day history of fever, right-sided abdominal pain, and diarrhea. Cefotaxime antimicrobial chemotherapy was initiated as an empiric therapy targeting E. coli, the most frequent cause of community-onset pyelonephritis. Vancomycin (VCM) was started for acute focal bacterial nephritis caused by methicillin-resistant S. saprophyticus but was stopped due to allergy and replaced with DAP. After 13 days of treatment with DAP, the patient received 17 days of treatment with sulfamethoxazole-trimethoprim combination therapy. The patient experienced no adverse events and did not relapse. DAP is a relatively new anti-methicillin-resistant Staphylococcus aureus drug used to treat gram-positive cocci infections. It is primarily excreted by the kidneys, which may be desirable in treating urinary tract infections. For children who cannot receive VCM for any reason, DAP may be a viable alternative.
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spelling pubmed-93727292022-08-13 A case of acute focal bacterial nephritis caused by methicillin-resistant Staphylococcus saprophyticus in a 13-year-old adolescent girl treated with daptomycin Kinoshita, Teruhisa Sahara, Shoko Mihara, Yuka Asai, Yumiko Sato, Hiroko Sakakibara, Takashi Takimoto, Norio Oka, Keisuke IDCases Case Report Staphylococcus saprophyticus is a gram-positive, coagulase-negative member of the Staphylococcus genus and is second only to Escherichia coli as a cause of urinary tract infections in the young female population. S. saprophyticus usually has good susceptibility to drugs commonly used to treat urinary tract infections, but it is often methicillin-resistant. Here we report a case of acute focal bacterial nephritis in a 13-year-old female patient caused by methicillin-resistant S. saprophyticus and treated with daptomycin (DAP). The patient had a history of unilateral hearing loss and presented to her previous physician with a 3-day history of fever, right-sided abdominal pain, and diarrhea. Cefotaxime antimicrobial chemotherapy was initiated as an empiric therapy targeting E. coli, the most frequent cause of community-onset pyelonephritis. Vancomycin (VCM) was started for acute focal bacterial nephritis caused by methicillin-resistant S. saprophyticus but was stopped due to allergy and replaced with DAP. After 13 days of treatment with DAP, the patient received 17 days of treatment with sulfamethoxazole-trimethoprim combination therapy. The patient experienced no adverse events and did not relapse. DAP is a relatively new anti-methicillin-resistant Staphylococcus aureus drug used to treat gram-positive cocci infections. It is primarily excreted by the kidneys, which may be desirable in treating urinary tract infections. For children who cannot receive VCM for any reason, DAP may be a viable alternative. Elsevier 2022-08-06 /pmc/articles/PMC9372729/ /pubmed/35966278 http://dx.doi.org/10.1016/j.idcr.2022.e01594 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kinoshita, Teruhisa
Sahara, Shoko
Mihara, Yuka
Asai, Yumiko
Sato, Hiroko
Sakakibara, Takashi
Takimoto, Norio
Oka, Keisuke
A case of acute focal bacterial nephritis caused by methicillin-resistant Staphylococcus saprophyticus in a 13-year-old adolescent girl treated with daptomycin
title A case of acute focal bacterial nephritis caused by methicillin-resistant Staphylococcus saprophyticus in a 13-year-old adolescent girl treated with daptomycin
title_full A case of acute focal bacterial nephritis caused by methicillin-resistant Staphylococcus saprophyticus in a 13-year-old adolescent girl treated with daptomycin
title_fullStr A case of acute focal bacterial nephritis caused by methicillin-resistant Staphylococcus saprophyticus in a 13-year-old adolescent girl treated with daptomycin
title_full_unstemmed A case of acute focal bacterial nephritis caused by methicillin-resistant Staphylococcus saprophyticus in a 13-year-old adolescent girl treated with daptomycin
title_short A case of acute focal bacterial nephritis caused by methicillin-resistant Staphylococcus saprophyticus in a 13-year-old adolescent girl treated with daptomycin
title_sort case of acute focal bacterial nephritis caused by methicillin-resistant staphylococcus saprophyticus in a 13-year-old adolescent girl treated with daptomycin
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372729/
https://www.ncbi.nlm.nih.gov/pubmed/35966278
http://dx.doi.org/10.1016/j.idcr.2022.e01594
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