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Soluble guanylyl cyclase mediates noncanonical nitric oxide signaling by nitrosothiol transfer under oxidative stress

Soluble guanylyl cyclase (GC1) is an α/β heterodimer producing cGMP when stimulated by nitric oxide (NO). The NO-GC1-cGMP pathway is essential for cardiovascular homeostasis but is disrupted by oxidative stress, which causes GC1 desensitization to NO by heme oxidation and S-nitrosation (SNO) of spec...

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Detalles Bibliográficos
Autores principales:	Cui, Chuanlong, Wu, Changgong, Shu, Ping, Liu, Tong, Li, Hong, Beuve, Annie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372771/ https://www.ncbi.nlm.nih.gov/pubmed/35961098 http://dx.doi.org/10.1016/j.redox.2022.102425

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