Empagliflozin activates Wnt/β-catenin to stimulate FUNDC1-dependent mitochondrial quality surveillance against type-3 cardiorenal syndrome

OBJECTIVES: Cardiorenal syndrome type-3 (CRS-3) is an abrupt worsening of cardiac function secondary to acute kidney injury. Mitochondrial dysfunction is a key pathological mechanism of CRS-3, and empagliflozin can improve mitochondrial biology by promoting mitophagy. Here, we assessed the effects o...

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Detalles Bibliográficos
Autores principales: Cai, Chen, Wu, Feng, Zhuang, Bingjie, Ou, Qing, Peng, Xiaojie, Shi, Nengxian, Peng, Lan, Li, Ziying, Wang, Jin, Cai, Shumin, Tan, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372775/
https://www.ncbi.nlm.nih.gov/pubmed/35863636
http://dx.doi.org/10.1016/j.molmet.2022.101553

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