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Long-term survival of gastric mixed neuroendocrine-non-neuroendocrine neoplasm: Two case reports
BACKGROUND: Gastric mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN), which consists of neuroendocrine and non-neuroendocrine components, is quite rare. Until now, most data on gastric MiNEN come from clinical cases, without large-scale retrospective studies or controlled clinical trials. Co...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372867/ https://www.ncbi.nlm.nih.gov/pubmed/36158478 http://dx.doi.org/10.12998/wjcc.v10.i22.7936 |
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author | Woo, Lun-Tao Ding, Yong-Feng Mao, Chen-Yu Qian, Jiong Zhang, Xiu-Ming Xu, Nong |
author_facet | Woo, Lun-Tao Ding, Yong-Feng Mao, Chen-Yu Qian, Jiong Zhang, Xiu-Ming Xu, Nong |
author_sort | Woo, Lun-Tao |
collection | PubMed |
description | BACKGROUND: Gastric mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN), which consists of neuroendocrine and non-neuroendocrine components, is quite rare. Until now, most data on gastric MiNEN come from clinical cases, without large-scale retrospective studies or controlled clinical trials. Consequently, no consensus regarding the origin, molecular characteristics, or appropriate treatment of MiNEN has been reached so far. We conducted chemotherapy of irinotecan plus cisplatin (IP regimen) and surgery in two patients with gastric MiNEN, which had never been used in treating this kind of tumor, leading to their long-term survival for more than 3 and 7 years, respectively. CASE SUMMARY: We present two patients (one male and one female) with gastric MiNEN, with the primary manifestation of recurrent upper abdominal pain. After they were referred to our hospital, a diagnosis of gastric MiNEN was defined with the help of CT scan, and histopathological and immunohistochemical examinations on the samples of gastrointestinal endoscopy or radical surgery. The male patient (case 1) were found to have metastases in the reginal lymph nodes and the left liver. He received four cycles of IP regimens first, then the gastrectomy and partial left liver resection, followed by additional two cycles of IP chemotherapy. The female patient (case 2) underwent a laparoscopic gastrectomy, and received six cycles of IP regimen. She was found to have metastatic lesions in the right lung 2 years after that, and underwent video-assisted thoracoscopic surgery (VATS) of the lower lobe of the right lung. The two patients have now survived for more than 3 years and 7 years, respectively, without any evidence of recurrence or metastases. CONCLUSION: IP regimen, combined with curative-intent surgery if feasible, could be considered as the priority in the choice of front-line chemotherapy for gastric MiNEN. |
format | Online Article Text |
id | pubmed-9372867 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-93728672022-09-23 Long-term survival of gastric mixed neuroendocrine-non-neuroendocrine neoplasm: Two case reports Woo, Lun-Tao Ding, Yong-Feng Mao, Chen-Yu Qian, Jiong Zhang, Xiu-Ming Xu, Nong World J Clin Cases Case Report BACKGROUND: Gastric mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN), which consists of neuroendocrine and non-neuroendocrine components, is quite rare. Until now, most data on gastric MiNEN come from clinical cases, without large-scale retrospective studies or controlled clinical trials. Consequently, no consensus regarding the origin, molecular characteristics, or appropriate treatment of MiNEN has been reached so far. We conducted chemotherapy of irinotecan plus cisplatin (IP regimen) and surgery in two patients with gastric MiNEN, which had never been used in treating this kind of tumor, leading to their long-term survival for more than 3 and 7 years, respectively. CASE SUMMARY: We present two patients (one male and one female) with gastric MiNEN, with the primary manifestation of recurrent upper abdominal pain. After they were referred to our hospital, a diagnosis of gastric MiNEN was defined with the help of CT scan, and histopathological and immunohistochemical examinations on the samples of gastrointestinal endoscopy or radical surgery. The male patient (case 1) were found to have metastases in the reginal lymph nodes and the left liver. He received four cycles of IP regimens first, then the gastrectomy and partial left liver resection, followed by additional two cycles of IP chemotherapy. The female patient (case 2) underwent a laparoscopic gastrectomy, and received six cycles of IP regimen. She was found to have metastatic lesions in the right lung 2 years after that, and underwent video-assisted thoracoscopic surgery (VATS) of the lower lobe of the right lung. The two patients have now survived for more than 3 years and 7 years, respectively, without any evidence of recurrence or metastases. CONCLUSION: IP regimen, combined with curative-intent surgery if feasible, could be considered as the priority in the choice of front-line chemotherapy for gastric MiNEN. Baishideng Publishing Group Inc 2022-08-06 2022-08-06 /pmc/articles/PMC9372867/ /pubmed/36158478 http://dx.doi.org/10.12998/wjcc.v10.i22.7936 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Case Report Woo, Lun-Tao Ding, Yong-Feng Mao, Chen-Yu Qian, Jiong Zhang, Xiu-Ming Xu, Nong Long-term survival of gastric mixed neuroendocrine-non-neuroendocrine neoplasm: Two case reports |
title | Long-term survival of gastric mixed neuroendocrine-non-neuroendocrine neoplasm: Two case reports |
title_full | Long-term survival of gastric mixed neuroendocrine-non-neuroendocrine neoplasm: Two case reports |
title_fullStr | Long-term survival of gastric mixed neuroendocrine-non-neuroendocrine neoplasm: Two case reports |
title_full_unstemmed | Long-term survival of gastric mixed neuroendocrine-non-neuroendocrine neoplasm: Two case reports |
title_short | Long-term survival of gastric mixed neuroendocrine-non-neuroendocrine neoplasm: Two case reports |
title_sort | long-term survival of gastric mixed neuroendocrine-non-neuroendocrine neoplasm: two case reports |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372867/ https://www.ncbi.nlm.nih.gov/pubmed/36158478 http://dx.doi.org/10.12998/wjcc.v10.i22.7936 |
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