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Role of micronutrients in Alzheimer's disease: Review of available evidence
Alzheimer's disease (AD) is one of the most common age-related neurodegenerative disorders that have been studied for more than 100 years. Although an increased level of amyloid precursor protein is considered a key contributor to the development of AD, the exact pathogenic mechanism remains kn...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372870/ https://www.ncbi.nlm.nih.gov/pubmed/36158513 http://dx.doi.org/10.12998/wjcc.v10.i22.7631 |
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author | Fei, Hong-Xin Qian, Chao-Fan Wu, Xiang-Mei Wei, Yu-Hua Huang, Jin-Yu Wei, Li-Hua |
author_facet | Fei, Hong-Xin Qian, Chao-Fan Wu, Xiang-Mei Wei, Yu-Hua Huang, Jin-Yu Wei, Li-Hua |
author_sort | Fei, Hong-Xin |
collection | PubMed |
description | Alzheimer's disease (AD) is one of the most common age-related neurodegenerative disorders that have been studied for more than 100 years. Although an increased level of amyloid precursor protein is considered a key contributor to the development of AD, the exact pathogenic mechanism remains known. Multiple factors are related to AD, such as genetic factors, aging, lifestyle, and nutrients. Both epidemiological and clinical evidence has shown that the levels of micronutrients, such as copper, zinc, and iron, are closely related to the development of AD. In this review, we summarize the roles of eight micronutrients, including copper, zinc, iron, selenium, silicon, manganese, arsenic, and vitamin D in AD based on recently published studies. |
format | Online Article Text |
id | pubmed-9372870 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-93728702022-09-23 Role of micronutrients in Alzheimer's disease: Review of available evidence Fei, Hong-Xin Qian, Chao-Fan Wu, Xiang-Mei Wei, Yu-Hua Huang, Jin-Yu Wei, Li-Hua World J Clin Cases Review Alzheimer's disease (AD) is one of the most common age-related neurodegenerative disorders that have been studied for more than 100 years. Although an increased level of amyloid precursor protein is considered a key contributor to the development of AD, the exact pathogenic mechanism remains known. Multiple factors are related to AD, such as genetic factors, aging, lifestyle, and nutrients. Both epidemiological and clinical evidence has shown that the levels of micronutrients, such as copper, zinc, and iron, are closely related to the development of AD. In this review, we summarize the roles of eight micronutrients, including copper, zinc, iron, selenium, silicon, manganese, arsenic, and vitamin D in AD based on recently published studies. Baishideng Publishing Group Inc 2022-08-06 2022-08-06 /pmc/articles/PMC9372870/ /pubmed/36158513 http://dx.doi.org/10.12998/wjcc.v10.i22.7631 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Review Fei, Hong-Xin Qian, Chao-Fan Wu, Xiang-Mei Wei, Yu-Hua Huang, Jin-Yu Wei, Li-Hua Role of micronutrients in Alzheimer's disease: Review of available evidence |
title | Role of micronutrients in Alzheimer's disease: Review of available evidence |
title_full | Role of micronutrients in Alzheimer's disease: Review of available evidence |
title_fullStr | Role of micronutrients in Alzheimer's disease: Review of available evidence |
title_full_unstemmed | Role of micronutrients in Alzheimer's disease: Review of available evidence |
title_short | Role of micronutrients in Alzheimer's disease: Review of available evidence |
title_sort | role of micronutrients in alzheimer's disease: review of available evidence |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372870/ https://www.ncbi.nlm.nih.gov/pubmed/36158513 http://dx.doi.org/10.12998/wjcc.v10.i22.7631 |
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