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Role of micronutrients in Alzheimer's disease: Review of available evidence

Alzheimer's disease (AD) is one of the most common age-related neurodegenerative disorders that have been studied for more than 100 years. Although an increased level of amyloid precursor protein is considered a key contributor to the development of AD, the exact pathogenic mechanism remains kn...

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Autores principales: Fei, Hong-Xin, Qian, Chao-Fan, Wu, Xiang-Mei, Wei, Yu-Hua, Huang, Jin-Yu, Wei, Li-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372870/
https://www.ncbi.nlm.nih.gov/pubmed/36158513
http://dx.doi.org/10.12998/wjcc.v10.i22.7631
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author Fei, Hong-Xin
Qian, Chao-Fan
Wu, Xiang-Mei
Wei, Yu-Hua
Huang, Jin-Yu
Wei, Li-Hua
author_facet Fei, Hong-Xin
Qian, Chao-Fan
Wu, Xiang-Mei
Wei, Yu-Hua
Huang, Jin-Yu
Wei, Li-Hua
author_sort Fei, Hong-Xin
collection PubMed
description Alzheimer's disease (AD) is one of the most common age-related neurodegenerative disorders that have been studied for more than 100 years. Although an increased level of amyloid precursor protein is considered a key contributor to the development of AD, the exact pathogenic mechanism remains known. Multiple factors are related to AD, such as genetic factors, aging, lifestyle, and nutrients. Both epidemiological and clinical evidence has shown that the levels of micronutrients, such as copper, zinc, and iron, are closely related to the development of AD. In this review, we summarize the roles of eight micronutrients, including copper, zinc, iron, selenium, silicon, manganese, arsenic, and vitamin D in AD based on recently published studies.
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spelling pubmed-93728702022-09-23 Role of micronutrients in Alzheimer's disease: Review of available evidence Fei, Hong-Xin Qian, Chao-Fan Wu, Xiang-Mei Wei, Yu-Hua Huang, Jin-Yu Wei, Li-Hua World J Clin Cases Review Alzheimer's disease (AD) is one of the most common age-related neurodegenerative disorders that have been studied for more than 100 years. Although an increased level of amyloid precursor protein is considered a key contributor to the development of AD, the exact pathogenic mechanism remains known. Multiple factors are related to AD, such as genetic factors, aging, lifestyle, and nutrients. Both epidemiological and clinical evidence has shown that the levels of micronutrients, such as copper, zinc, and iron, are closely related to the development of AD. In this review, we summarize the roles of eight micronutrients, including copper, zinc, iron, selenium, silicon, manganese, arsenic, and vitamin D in AD based on recently published studies. Baishideng Publishing Group Inc 2022-08-06 2022-08-06 /pmc/articles/PMC9372870/ /pubmed/36158513 http://dx.doi.org/10.12998/wjcc.v10.i22.7631 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Fei, Hong-Xin
Qian, Chao-Fan
Wu, Xiang-Mei
Wei, Yu-Hua
Huang, Jin-Yu
Wei, Li-Hua
Role of micronutrients in Alzheimer's disease: Review of available evidence
title Role of micronutrients in Alzheimer's disease: Review of available evidence
title_full Role of micronutrients in Alzheimer's disease: Review of available evidence
title_fullStr Role of micronutrients in Alzheimer's disease: Review of available evidence
title_full_unstemmed Role of micronutrients in Alzheimer's disease: Review of available evidence
title_short Role of micronutrients in Alzheimer's disease: Review of available evidence
title_sort role of micronutrients in alzheimer's disease: review of available evidence
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372870/
https://www.ncbi.nlm.nih.gov/pubmed/36158513
http://dx.doi.org/10.12998/wjcc.v10.i22.7631
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