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Improving antibody thermostability based on statistical analysis of sequence and structural consensus data
BACKGROUND: The use of Monoclonal Antibodies (MAbs) as therapeutics has been increasing over the past 30 years due to their high specificity and strong affinity toward the target. One of the major challenges toward their use as drugs is their low thermostability, which impacts both efficacy as well...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372885/ https://www.ncbi.nlm.nih.gov/pubmed/35967906 http://dx.doi.org/10.1093/abt/tbac017 |