Inflammatory platelet death drives sepsis

Thrombocytopenia is common in severe sepsis and is associated with an increased risk of mortality. A new study shows that platelet pyroptosis initiated during infection promotes a feedforward loop of neutrophil-mediated inflammation that worsens outcomes during sepsis.

Detalles Bibliográficos
Autores principales: Brown, Luke, Yipp, Bryan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
News & Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372963/
https://www.ncbi.nlm.nih.gov/pubmed/35975232
http://dx.doi.org/10.1038/s44161-022-00111-y
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author Brown, Luke
Yipp, Bryan G.
author_facet Brown, Luke
Yipp, Bryan G.
author_sort Brown, Luke
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description Thrombocytopenia is common in severe sepsis and is associated with an increased risk of mortality. A new study shows that platelet pyroptosis initiated during infection promotes a feedforward loop of neutrophil-mediated inflammation that worsens outcomes during sepsis.
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spelling pubmed-93729632022-08-12 Inflammatory platelet death drives sepsis Brown, Luke Yipp, Bryan G. Nat Cardiovasc Res News & Views Thrombocytopenia is common in severe sepsis and is associated with an increased risk of mortality. A new study shows that platelet pyroptosis initiated during infection promotes a feedforward loop of neutrophil-mediated inflammation that worsens outcomes during sepsis. Nature Publishing Group UK 2022-08-04 2022 /pmc/articles/PMC9372963/ /pubmed/35975232 http://dx.doi.org/10.1038/s44161-022-00111-y Text en © Springer Nature Limited 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle News & Views
Brown, Luke
Yipp, Bryan G.
Inflammatory platelet death drives sepsis
title Inflammatory platelet death drives sepsis
title_full Inflammatory platelet death drives sepsis
title_fullStr Inflammatory platelet death drives sepsis
title_full_unstemmed Inflammatory platelet death drives sepsis
title_short Inflammatory platelet death drives sepsis
title_sort inflammatory platelet death drives sepsis
topic News & Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372963/
https://www.ncbi.nlm.nih.gov/pubmed/35975232
http://dx.doi.org/10.1038/s44161-022-00111-y
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