Mesenchymal stem cells and their derived small extracellular vesicles for COVID-19 treatment

Since December 2019, the coronavirus (COVID-19) pandemic has imposed huge burdens to the whole world, seriously affecting global economic growth, and threatening people’s lives and health. At present, some therapeutic regimens are available for treatment of COVID-19 pneumonia, including antiviral th...

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Detalles Bibliográficos
Autores principales: Huang, Yuling, Li, Xin, Yang, Lina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372991/
https://www.ncbi.nlm.nih.gov/pubmed/35962458
http://dx.doi.org/10.1186/s13287-022-03034-4
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author Huang, Yuling
Li, Xin
Yang, Lina
author_facet Huang, Yuling
Li, Xin
Yang, Lina
author_sort Huang, Yuling
collection PubMed
description Since December 2019, the coronavirus (COVID-19) pandemic has imposed huge burdens to the whole world, seriously affecting global economic growth, and threatening people’s lives and health. At present, some therapeutic regimens are available for treatment of COVID-19 pneumonia, including antiviral therapy, immunity therapy, anticoagulant therapy, and others. Among them, injection of mesenchymal stem cells (MSCs) is currently a promising therapy. The preclinical studies and clinical trials using MSCs and small extracellular vesicles derived from MSCs (MSC-sEVs) in treating COVID-19 were summarized. Then, the molecular mechanism, feasibility, and safety of treating COVID-19 with MSCs and MSC-sEVs were also discussed.
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spelling pubmed-93729912022-08-12 Mesenchymal stem cells and their derived small extracellular vesicles for COVID-19 treatment Huang, Yuling Li, Xin Yang, Lina Stem Cell Res Ther Review Since December 2019, the coronavirus (COVID-19) pandemic has imposed huge burdens to the whole world, seriously affecting global economic growth, and threatening people’s lives and health. At present, some therapeutic regimens are available for treatment of COVID-19 pneumonia, including antiviral therapy, immunity therapy, anticoagulant therapy, and others. Among them, injection of mesenchymal stem cells (MSCs) is currently a promising therapy. The preclinical studies and clinical trials using MSCs and small extracellular vesicles derived from MSCs (MSC-sEVs) in treating COVID-19 were summarized. Then, the molecular mechanism, feasibility, and safety of treating COVID-19 with MSCs and MSC-sEVs were also discussed. BioMed Central 2022-08-12 /pmc/articles/PMC9372991/ /pubmed/35962458 http://dx.doi.org/10.1186/s13287-022-03034-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Huang, Yuling
Li, Xin
Yang, Lina
Mesenchymal stem cells and their derived small extracellular vesicles for COVID-19 treatment
title Mesenchymal stem cells and their derived small extracellular vesicles for COVID-19 treatment
title_full Mesenchymal stem cells and their derived small extracellular vesicles for COVID-19 treatment
title_fullStr Mesenchymal stem cells and their derived small extracellular vesicles for COVID-19 treatment
title_full_unstemmed Mesenchymal stem cells and their derived small extracellular vesicles for COVID-19 treatment
title_short Mesenchymal stem cells and their derived small extracellular vesicles for COVID-19 treatment
title_sort mesenchymal stem cells and their derived small extracellular vesicles for covid-19 treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9372991/
https://www.ncbi.nlm.nih.gov/pubmed/35962458
http://dx.doi.org/10.1186/s13287-022-03034-4
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