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The value of diffusion kurtosis imaging, diffusion weighted imaging and (18)F-FDG PET for differentiating benign and malignant solitary pulmonary lesions and predicting pathological grading

OBJECTIVE: To explore the value of PET/MRI, including diffusion kurtosis imaging (DKI), diffusion weighted imaging (DWI) and positron emission tomography (PET), for distinguishing between benign and malignant solitary pulmonary lesions (SPLs) and predicting the histopathological grading of malignant...

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Autores principales: Li, Ziqiang, Luo, Yu, Jiang, Han, Meng, Nan, Huang, Zhun, Feng, Pengyang, Fang, Ting, Fu, Fangfang, Li, Xiaochen, Bai, Yan, Wei, Wei, Yang, Yang, Yuan, Jianmin, Cheng, Jianjian, Wang, Meiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373010/
https://www.ncbi.nlm.nih.gov/pubmed/35965564
http://dx.doi.org/10.3389/fonc.2022.873669
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author Li, Ziqiang
Luo, Yu
Jiang, Han
Meng, Nan
Huang, Zhun
Feng, Pengyang
Fang, Ting
Fu, Fangfang
Li, Xiaochen
Bai, Yan
Wei, Wei
Yang, Yang
Yuan, Jianmin
Cheng, Jianjian
Wang, Meiyun
author_facet Li, Ziqiang
Luo, Yu
Jiang, Han
Meng, Nan
Huang, Zhun
Feng, Pengyang
Fang, Ting
Fu, Fangfang
Li, Xiaochen
Bai, Yan
Wei, Wei
Yang, Yang
Yuan, Jianmin
Cheng, Jianjian
Wang, Meiyun
author_sort Li, Ziqiang
collection PubMed
description OBJECTIVE: To explore the value of PET/MRI, including diffusion kurtosis imaging (DKI), diffusion weighted imaging (DWI) and positron emission tomography (PET), for distinguishing between benign and malignant solitary pulmonary lesions (SPLs) and predicting the histopathological grading of malignant SPLs. MATERIAL AND METHODS: Chest PET, DKI and DWI scans of 73 patients with SPL were performed by PET/MRI. The apparent diffusion coefficient (ADC), mean diffusivity (MD), mean kurtosis (MK), maximum standard uptake value (SUV(max)), metabolic total volume (MTV) and total lesion glycolysis (TLG) were calculated. Student’s t test or the Mann–Whitney U test was used to analyze the differences in parameters between groups. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic efficacy. Logistic regression analysis was used to evaluate independent predictors. RESULTS: The MK and SUV(max) were significantly higher, and the MD and ADC were significantly lower in the malignant group (0.59 ± 0.13, 10.25 ± 4.20, 2.27 ± 0.51[×10(-3) mm(2)/s] and 1.35 ± 0.33 [×10(-3) mm(2)/s]) compared to the benign group (0.47 ± 0.08, 5.49 ± 4.05, 2.85 ± 0.60 [×10(-3) mm(2)/s] and 1.67 ± 0.33 [×10(-3) mm(2)/s]). The MD and ADC were significantly lower, and the MTV and TLG were significantly higher in the high-grade malignant SPLs group (2.11 ± 0.51 [×10(-3) mm(2)/s], 1.35 ± 0.33 [×10(-3) mm(2)/s], 35.87 ± 42.24 and 119.58 ± 163.65) than in the non-high-grade malignant SPLs group (2.46 ± 0.46 [×10(-3) mm(2)/s], 1.67 ± 0.33[×10(-3) mm(2)/s], 20.17 ± 32.34 and 114.20 ± 178.68). In the identification of benign and malignant SPLs, the SUV(max) and MK were independent predictors, the AUCs of the combination of SUV(max) and MK, SUV(max), MK, MD, and ADC were 0.875, 0.787, 0.848, 0.769, and 0.822, respectively. In the identification of high-grade and non-high-grade malignant SPLs, the AUCs of MD, ADC, MTV, and TLG were 0.729, 0.680, 0.693, and 0.711, respectively. CONCLUSION: DWI, DKI, and PET in PET/MRI are all effective methods to distinguish benign from malignant SPLs, and are also helpful in evaluating the pathological grading of malignant SPLs.
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spelling pubmed-93730102022-08-13 The value of diffusion kurtosis imaging, diffusion weighted imaging and (18)F-FDG PET for differentiating benign and malignant solitary pulmonary lesions and predicting pathological grading Li, Ziqiang Luo, Yu Jiang, Han Meng, Nan Huang, Zhun Feng, Pengyang Fang, Ting Fu, Fangfang Li, Xiaochen Bai, Yan Wei, Wei Yang, Yang Yuan, Jianmin Cheng, Jianjian Wang, Meiyun Front Oncol Oncology OBJECTIVE: To explore the value of PET/MRI, including diffusion kurtosis imaging (DKI), diffusion weighted imaging (DWI) and positron emission tomography (PET), for distinguishing between benign and malignant solitary pulmonary lesions (SPLs) and predicting the histopathological grading of malignant SPLs. MATERIAL AND METHODS: Chest PET, DKI and DWI scans of 73 patients with SPL were performed by PET/MRI. The apparent diffusion coefficient (ADC), mean diffusivity (MD), mean kurtosis (MK), maximum standard uptake value (SUV(max)), metabolic total volume (MTV) and total lesion glycolysis (TLG) were calculated. Student’s t test or the Mann–Whitney U test was used to analyze the differences in parameters between groups. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic efficacy. Logistic regression analysis was used to evaluate independent predictors. RESULTS: The MK and SUV(max) were significantly higher, and the MD and ADC were significantly lower in the malignant group (0.59 ± 0.13, 10.25 ± 4.20, 2.27 ± 0.51[×10(-3) mm(2)/s] and 1.35 ± 0.33 [×10(-3) mm(2)/s]) compared to the benign group (0.47 ± 0.08, 5.49 ± 4.05, 2.85 ± 0.60 [×10(-3) mm(2)/s] and 1.67 ± 0.33 [×10(-3) mm(2)/s]). The MD and ADC were significantly lower, and the MTV and TLG were significantly higher in the high-grade malignant SPLs group (2.11 ± 0.51 [×10(-3) mm(2)/s], 1.35 ± 0.33 [×10(-3) mm(2)/s], 35.87 ± 42.24 and 119.58 ± 163.65) than in the non-high-grade malignant SPLs group (2.46 ± 0.46 [×10(-3) mm(2)/s], 1.67 ± 0.33[×10(-3) mm(2)/s], 20.17 ± 32.34 and 114.20 ± 178.68). In the identification of benign and malignant SPLs, the SUV(max) and MK were independent predictors, the AUCs of the combination of SUV(max) and MK, SUV(max), MK, MD, and ADC were 0.875, 0.787, 0.848, 0.769, and 0.822, respectively. In the identification of high-grade and non-high-grade malignant SPLs, the AUCs of MD, ADC, MTV, and TLG were 0.729, 0.680, 0.693, and 0.711, respectively. CONCLUSION: DWI, DKI, and PET in PET/MRI are all effective methods to distinguish benign from malignant SPLs, and are also helpful in evaluating the pathological grading of malignant SPLs. Frontiers Media S.A. 2022-07-29 /pmc/articles/PMC9373010/ /pubmed/35965564 http://dx.doi.org/10.3389/fonc.2022.873669 Text en Copyright © 2022 Li, Luo, Jiang, Meng, Huang, Feng, Fang, Fu, Li, Bai, Wei, Yang, Yuan, Cheng and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Li, Ziqiang
Luo, Yu
Jiang, Han
Meng, Nan
Huang, Zhun
Feng, Pengyang
Fang, Ting
Fu, Fangfang
Li, Xiaochen
Bai, Yan
Wei, Wei
Yang, Yang
Yuan, Jianmin
Cheng, Jianjian
Wang, Meiyun
The value of diffusion kurtosis imaging, diffusion weighted imaging and (18)F-FDG PET for differentiating benign and malignant solitary pulmonary lesions and predicting pathological grading
title The value of diffusion kurtosis imaging, diffusion weighted imaging and (18)F-FDG PET for differentiating benign and malignant solitary pulmonary lesions and predicting pathological grading
title_full The value of diffusion kurtosis imaging, diffusion weighted imaging and (18)F-FDG PET for differentiating benign and malignant solitary pulmonary lesions and predicting pathological grading
title_fullStr The value of diffusion kurtosis imaging, diffusion weighted imaging and (18)F-FDG PET for differentiating benign and malignant solitary pulmonary lesions and predicting pathological grading
title_full_unstemmed The value of diffusion kurtosis imaging, diffusion weighted imaging and (18)F-FDG PET for differentiating benign and malignant solitary pulmonary lesions and predicting pathological grading
title_short The value of diffusion kurtosis imaging, diffusion weighted imaging and (18)F-FDG PET for differentiating benign and malignant solitary pulmonary lesions and predicting pathological grading
title_sort value of diffusion kurtosis imaging, diffusion weighted imaging and (18)f-fdg pet for differentiating benign and malignant solitary pulmonary lesions and predicting pathological grading
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373010/
https://www.ncbi.nlm.nih.gov/pubmed/35965564
http://dx.doi.org/10.3389/fonc.2022.873669
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